Next Article in Journal / Special Issue
Pathological Mutations of the Mitochondrial Human Genome: the Instrumental Role of the Yeast S. cerevisiae
Previous Article in Journal
Diseases — the Reasons for a New Challenge in Open Access Medicine Research
Previous Article in Special Issue
Effect of Cardio-Metabolic Risk Factors Clustering with or without Arterial Hypertension on Arterial Stiffness: A Narrative Review
Article Menu

Export Article

Open AccessReview
Diseases 2014, 2(1), 3-23; doi:10.3390/diseases2010003

Trypanosomatid Aquaporins: Roles in Physiology and Drug Response

Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL 33199, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 2 December 2013 / Revised: 22 December 2013 / Accepted: 24 December 2013 / Published: 27 December 2013
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [1300 KB, uploaded 27 December 2013]   |  


In the class Kinetoplastida, we find an order of parasitic protozoans classified as Trypanosomatids. Three major pathogens form part of this order, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania, which are responsible for disease and fatalities in millions of humans worldwide, especially in non-industrialized countries in tropical and sub-tropical regions. In order to develop new drugs and treatments, the physiology of these pathogenic protozoans has been studied in detail, specifically the significance of membrane transporters in host parasites interactions. Aquaporins and Aquaglyceroporins (AQPs) are a part of the major intrinsic proteins (MIPs) super-family. AQPs are characterized for their ability to facilitate the diffusion of water (aquaporin), glycerol (aquaglyceroporin), and other small-uncharged solutes. Furthermore, AQPs have been shown to allow the ubiquitous passage of some metalloids, such as trivalent arsenic and antimony. These trivalent metalloids are the active ingredient of a number of chemotherapeutic agents used against certain cancers and protozoan parasitic infections. Recently, the importance of the AQPs not only in osmotic adaptations but also as a factor in drug resistance of the trypanosomatid parasites has been reported. In this review, we will describe the physiological functions of aquaporins and their effect in drug response across the different trypanosomatids.
Keywords: aquaporin; Aquaglyceroporin; drug resistance; Leishmania; Trypanosoma; Pentostam; antimony aquaporin; Aquaglyceroporin; drug resistance; Leishmania; Trypanosoma; Pentostam; antimony

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mandal, G.; Orta, J.F.; Sharma, M.; Mukhopadhyay, R. Trypanosomatid Aquaporins: Roles in Physiology and Drug Response. Diseases 2014, 2, 3-23.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top