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Diseases 2014, 2(1), 24-44; doi:10.3390/diseases2010024

Pathological Mutations of the Mitochondrial Human Genome: the Instrumental Role of the Yeast S. cerevisiae

Université Paris-Sud, Institut de Génétique et Microbiologie. Batiment 400, Orsay Cedex 91405, France
Received: 8 November 2013 / Revised: 9 January 2014 / Accepted: 10 January 2014 / Published: 22 January 2014
(This article belongs to the Special Issue Feature Papers)
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Abstract

Mitochondrial diseases, which altogether represent not so rare diseases, can be due to mutations either in the nuclear or mitochondrial genomes. Several model organisms or cell lines are usually employed to understand the mechanisms underlying diseases, yeast being one of them. However, in the case of mutations within the mitochondrial genome, yeast is a major model because it is a facultative aerobe and its mitochondrial genome can be genetically engineered and reintroduced in vivo. In this short review, I will describe how these properties can be exploited to mimic mitochondrial pathogenic mutations, as well as their limits. In particular; pathological mutations of tRNA, cytb, and ATPase genes have been successfully modeled. It is essential to stress that what has been discovered with yeast (molecular mechanisms underlying the diseases, nuclear correcting genes, import of tRNA into mitochondria or compounds from drug screening) has been successfully transferred to human patient lines, paving the way for future therapies. View Full-Text
Keywords: mitochondrial diseases; mitochondrial transformation; tRNA import; tRNA mutants; ATPase mutants; correcting genes; drug screening; mitochondrial therapies mitochondrial diseases; mitochondrial transformation; tRNA import; tRNA mutants; ATPase mutants; correcting genes; drug screening; mitochondrial therapies
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bolotin-Fukuhara, M. Pathological Mutations of the Mitochondrial Human Genome: the Instrumental Role of the Yeast S. cerevisiae. Diseases 2014, 2, 24-44.

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