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Cosmetics 2018, 5(2), 32; https://doi.org/10.3390/cosmetics5020032

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

1
Centre for Innovative Biotechnological Investigations Nano-Lab, 117437 Moscow, Russian
2
Department of Biology, Byelorussian State University, 220050 Minsk, Belarus
3
MEDENA AG, 8910 Affoltern-am-Albis, Switzerland
4
Healthyflora Ltd., R&D Department, London W11 2SH, UK
*
Author to whom correspondence should be addressed.
Received: 1 April 2018 / Revised: 20 April 2018 / Accepted: 23 April 2018 / Published: 2 May 2018
(This article belongs to the Special Issue Plants Used in Cosmetics)
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Abstract

Topical sun protective cosmetics (sunscreens, pre- and post-sun) have been intensively developed and produced to protect human skin against solar irradiation-associated damages/pathologies. Unfortunately, routine cosmetics for sun protection containing synthetic organic and/or physical sunscreens could exert adverse effects towards human organisms and bring undesirable ecological changes. Terrestrial and marine plant species, being exposed to sun light for hundreds of millions of years, have evolved two pro-survival strategies: effective protection against/adaptation to its deleterious effects and the use of solar energy for photosynthesis/photo-biochemical reactions. Secondary plant metabolites (SPM) are primary sensors of solar energy and mediators of its use (photo-sensitisers) or neutralisation (photo-protectors). A similar double photo-protective/photo-sensitising system is built in within human skin. Modern development of toxicologically/ecologically safe yet effective sun-protective cosmetics attempts to pre-select photo-stable and non-phototoxic SPMs that provide broad UVA + UVB sunscreen, free radical scavenging and direct antioxidant defence, endogenous antioxidant rescue, induction of antioxidant enzymes (indirect antioxidant defence), and normalisation of metabolic and immune responses to UVA + UVB. Proper formulation of sun protective cosmetics should assure targeted delivery of photo-active SPMs to definite skin layers to invigorate the built in photo-chemical skin barrier. View Full-Text
Keywords: marine and terrestrial plants; photo-protection; photo-sensitisation; photo-stability; secondary metabolites; skin antioxidants; skin metabolism; cosmetics formulation; UVA; UVB marine and terrestrial plants; photo-protection; photo-sensitisation; photo-stability; secondary metabolites; skin antioxidants; skin metabolism; cosmetics formulation; UVA; UVB
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Korkina, L.; Kostyuk, V.; Potapovich, A.; Mayer, W.; Talib, N.; De Luca, C. Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation. Cosmetics 2018, 5, 32.

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