Large Melanosome Complex Is Increased in Keratinocytes of Solar Lentigo
AbstractSolar lentigo (SL) is characterized by macular lesions exhibiting epidermal hyperplasia combined with hyperpigmentation along with irregular elongation of epidermal rete ridges. This study was conducted to assess the melanosomes in keratinocytes and the activation state of melanocytes in SL lesions on the backs of healthy Japanese individuals. Large melanosome complexes were increased in keratinocytes, and tyrosinase (TYR) activity, as well as immunohistochemical reactivity, for premelanosome protein 17 (Pmel17) in the SL lesions increased compared to the perilesions of five volunteers with SL. The levels of TYR, microphthalmia-associated transcription factor (MITF), and KIT mRNAs, but not stem cell factor (SCF) mRNA, were significantly increased in the SL lesions compared to the perilesions for all samples. Additionally, keratinocytes became immunoreactive to KIT in the rete ridge hyperplasia and basal layers of the SL lesions. These results suggested that the hyperpigmentation of SL arises primarily from increased melanogenesis of existing melanocytes in the basal layer of the epidermis, as well as increased large melanosome complexes in keratinocytes, which probably arise via an increase in KIT signaling in the epidermis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Maeda, K. Large Melanosome Complex Is Increased in Keratinocytes of Solar Lentigo. Cosmetics 2017, 4, 49.
Maeda K. Large Melanosome Complex Is Increased in Keratinocytes of Solar Lentigo. Cosmetics. 2017; 4(4):49.Chicago/Turabian Style
Maeda, Kazuhisa. 2017. "Large Melanosome Complex Is Increased in Keratinocytes of Solar Lentigo." Cosmetics 4, no. 4: 49.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.