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Erratum published on 22 March 2016, see Cosmetics 2016, 3(1), 12.

Open AccessArticle
Cosmetics 2015, 2(2), 66-81; doi:10.3390/cosmetics2020066

Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

1
Marinova Pty Ltd., 249 Kennedy Drive, Cambridge, Tasmania 7170, Australia
2
Dellacqua Consulting LLC, Jersey City, NJ 07302, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Received: 4 March 2015 / Revised: 2 April 2015 / Accepted: 2 April 2015 / Published: 16 April 2015
View Full-Text   |   Download PDF [786 KB, uploaded 16 April 2015]   |  

Abstract

Two concentrated and well-characterized fucoidan-rich extracts were investigated to determine their benefits in topical applications. An Undaria pinnatifida extract, containing 85% fucoidan, and a Fucus vesiculosus co-extract, containing 60% fucoidan and 30% polyphenol, were assessed in a number of in vitro assays to measure the effect of the extracts on enzyme inhibition, glycation, antioxidant activity and Sirtuin 1 (SIRT1) protein expression. Double-blind, placebo-controlled clinical studies were also conducted to measure soothing, protection, wrinkle depth, brightness and skin spot intensity. Both extracts demonstrated marked inhibitory effects on processes linked to skin aging, including the increased expression of SIRT1 in vitro. Clinical testing established the efficacy of the extracts in a range of the tested applications, relative to placebo. The Fucus vesiculosus extract with high polyphenol content demonstrated additional in vitro antioxidant activity, as well as improved efficacy in skin brightening applications, relative to placebo. The major effects of the Undaria pinnatifida extract aided skin immunity, soothing and protection, while the Fucus vesiculosus extract most significantly affected age spot reduction and increased brightness, soothing and protection. View Full-Text
Keywords: fucoidan; cell culture; skin physiology/structure; genetic analysis; polyphloroglucinol; superoxide; brightness; age spots fucoidan; cell culture; skin physiology/structure; genetic analysis; polyphloroglucinol; superoxide; brightness; age spots
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fitton, J.H.; Dell'Acqua, G.; Gardiner, V.-A.; Karpiniec, S.S.; Stringer, D.N.; Davis, E. Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae. Cosmetics 2015, 2, 66-81.

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