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Biology 2015, 4(4), 664-696; doi:10.3390/biology4040664

Nanodelivery Systems as New Tools for Immunostimulant or Vaccine Administration: Targeting the Fish Immune System

Institut de Biotecnologia i de Biomedicina-Parc de Recerca UAB, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
These authors contributed equally to this work.
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Academic Editor: Brian Dixon
Received: 28 August 2015 / Revised: 30 September 2015 / Accepted: 9 October 2015 / Published: 19 October 2015
(This article belongs to the Special Issue Current Topics in Fish Immunity)
View Full-Text   |   Download PDF [839 KB, uploaded 19 October 2015]

Abstract

Fish disease treatments have progressed significantly over the last few years and have moved from the massive use of antibiotics to the development of vaccines mainly based on inactivated bacteria. Today, the incorporation of immunostimulants and antigens into nanomaterials provide us with new tools to enhance the performance of immunostimulation. Nanoparticles are dispersions or solid particles designed with specific physical properties (size, surface charge, or loading capacity), which allow controlled delivery and therefore improved targeting and stimulation of the immune system. The use of these nanodelivery platforms in fish is in the initial steps of development. Here we review the advances in the application of nanoparticles to fish disease prevention including: the type of biomaterial, the type of immunostimulant or vaccine loaded into the nanoparticles, and how they target the fish immune system. View Full-Text
Keywords: nanoparticles; fish; immunostimulation; alginate; liposome; chitosan; PLGA; carbon nanotubes nanoparticles; fish; immunostimulation; alginate; liposome; chitosan; PLGA; carbon nanotubes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ji, J.; Torrealba, D.; Ruyra, À.; Roher, N. Nanodelivery Systems as New Tools for Immunostimulant or Vaccine Administration: Targeting the Fish Immune System. Biology 2015, 4, 664-696.

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