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Coatings 2017, 7(11), 182; https://doi.org/10.3390/coatings7110182

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

1
Department of Orthopedics, Jianhu Hospital Affiliated to Nantong University, Yancheng 224700, China
2
Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou 730000, China
3
Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81300, Malaysia
4
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
5
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
6
IJN-UTM Cardiovascular Engineering Centre, Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81300, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Mazeyar Parvinzadeh Gashti
Received: 18 August 2017 / Revised: 13 October 2017 / Accepted: 14 October 2017 / Published: 31 October 2017
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Abstract

Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE) incorporated with nano-hydroxyapaptite nanorods (mPE-nHA) was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscopy (AFM) and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT) was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT) by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications. View Full-Text
Keywords: metallocene polyethylene; hydroxyapatite nanorods; Aloe vera coating; bone tissue engineering metallocene polyethylene; hydroxyapatite nanorods; Aloe vera coating; bone tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, H.; Zhang, X.; Mani, M.P.; Jaganathan, S.K.; Huang, Y.; Wang, C. Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering. Coatings 2017, 7, 182.

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