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Antibiotics 2018, 7(1), 15; https://doi.org/10.3390/antibiotics7010015

Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy

1
Marine Biological Section, University of Copenhagen, DK-3000 Helsingør, Denmark
2
Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, 71500 Crete, Greece
*
Author to whom correspondence should be addressed.
Received: 1 February 2018 / Revised: 19 February 2018 / Accepted: 21 February 2018 / Published: 24 February 2018
(This article belongs to the Special Issue Bacteriophages: Alternatives to Antibiotics and Beyond)
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Abstract

A global distribution in marine, brackish, and freshwater ecosystems, in combination with high abundances and biomass, make vibrios key players in aquatic environments, as well as important pathogens for humans and marine animals. Incidents of Vibrio-associated diseases (vibriosis) in marine aquaculture are being increasingly reported on a global scale, due to the fast growth of the industry over the past few decades years. The administration of antibiotics has been the most commonly applied therapy used to control vibriosis outbreaks, giving rise to concerns about development and spreading of antibiotic-resistant bacteria in the environment. Hence, the idea of using lytic bacteriophages as therapeutic agents against bacterial diseases has been revived during the last years. Bacteriophage therapy constitutes a promising alternative not only for treatment, but also for prevention of vibriosis in aquaculture. However, several scientific and technological challenges still need further investigation before reliable, reproducible treatments with commercial potential are available for the aquaculture industry. The potential and the challenges of phage-based alternatives to antibiotic treatment of vibriosis are addressed in this review. View Full-Text
Keywords: marine vibrios; bacteriophages; phage therapy; biological control; aquaculture; interactions; vibriosis marine vibrios; bacteriophages; phage therapy; biological control; aquaculture; interactions; vibriosis
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Kalatzis, P.G.; Castillo, D.; Katharios, P.; Middelboe, M. Bacteriophage Interactions with Marine Pathogenic Vibrios: Implications for Phage Therapy. Antibiotics 2018, 7, 15.

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