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Antibiotics 2016, 5(4), 34; doi:10.3390/antibiotics5040034

Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus

1
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
2
Department of Lab Microbiology, Regions Hospital, Saint Paul, MN 55101, USA
3
Department of Pharmacy, Regions Hospital, Saint Paul, MN 55101, USA
4
Department of Medicine, Regions Hospital, Saint Paul, MN 55101, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 27 June 2016 / Revised: 15 September 2016 / Accepted: 20 September 2016 / Published: 27 September 2016
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Abstract

This study demonstrated a statistically significant difference in vancomycin minimum inhibitory concentration (MIC) for Staphylococcus aureus between a common automated system (Vitek 2) and the E-test method in patients with S. aureus bloodstream infections. At an area under the serum concentration time curve (AUC) threshold of 400 mg∙h/L, we would have reached the current Infectious Diseases Society of America (IDSA)/American Society of Health System Pharmacists (ASHP)/Society of Infectious Diseases Pharmacists (SIDP) guideline suggested AUC/MIC target in almost 100% of patients while using the Vitek 2 MIC data; however, we could only generate 40% target attainment while using E-test MIC data (p < 0.0001). An AUC of 450 mg∙h/L or greater was required to achieve 100% target attainment using either Vitek 2 or E-test MIC results. View Full-Text
Keywords: vancomycin; MIC; Staphylococcus aureus; susceptibility testing vancomycin; MIC; Staphylococcus aureus; susceptibility testing
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MDPI and ACS Style

Eum, S.; Bergsbaken, R.L.; Harvey, C.L.; Warren, J.B.; Rotschafer, J.C. Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus. Antibiotics 2016, 5, 34.

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