Next Article in Journal / Special Issue
Pectocin M1 (PcaM1) Inhibits Escherichia coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression
Previous Article in Journal
Discrepancy in Vancomycin AUC/MIC Ratio Targeted Attainment Based upon the Susceptibility Testing in Staphylococcus aureus
Previous Article in Special Issue
The Peptidoglycan Pattern of Staphylococcus carnosus TM300—Detailed Analysis and Variations Due to Genetic and Metabolic Influences
Article Menu

Export Article

Open AccessReview
Antibiotics 2016, 5(4), 35; doi:10.3390/antibiotics5040035

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins

1
Institut de Biologie Structurale (IBS), University Grenoble Alpes, CEA, CNRS, Grenoble 38044, France
2
Invasive Bacterial Infection and National Reference Center for Meningococci, Institut Pasteur, Paris 75015, France
*
Author to whom correspondence should be addressed.
Academic Editor: Waldemar Vollmer
Received: 20 July 2016 / Revised: 22 September 2016 / Accepted: 23 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Bacterial Cell Wall as Antimicrobial Target)
View Full-Text   |   Download PDF [2926 KB, uploaded 28 September 2016]   |  

Abstract

Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that cause a variety of life-threatening systemic and local infections, such as meningitis or gonorrhoea. The treatment of such infection is becoming more difficult due to antibiotic resistance. The focus of this review is on the mechanism of reduced susceptibility to penicillin and other β-lactams due to the modification of chromosomally encoded penicillin-binding proteins (PBP), in particular PBP2 encoded by the penA gene. The variety of penA alleles and resulting variant PBP2 enzymes is described and the important amino acid substitutions are presented and discussed in a structural context. View Full-Text
Keywords: Neisseria meningitidis; Neisseria gonorrhoeae; β-lactam resistance; penicillin-binding proteins Neisseria meningitidis; Neisseria gonorrhoeae; β-lactam resistance; penicillin-binding proteins
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zapun, A.; Morlot, C.; Taha, M.-K. Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins. Antibiotics 2016, 5, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top