Antibiotics 2013, 2(2), 288-315; doi:10.3390/antibiotics2020288
Review

Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance

1,2email, 1,2email and 1,2,* email
Received: 7 March 2013; in revised form: 21 May 2013 / Accepted: 23 May 2013 / Published: 30 May 2013
(This article belongs to the Special Issue Antibiotic Resistance)
View Full-Text   |   Download PDF [557 KB, uploaded 30 May 2013]
Abstract: The emergence of multi-resistant bacterial strains is a major source of concern and has been correlated with the widespread use of antibiotics. The origins of resistance are intensively studied and many mechanisms involved in resistance have been identified, such as exogenous gene acquisition by horizontal gene transfer (HGT), mutations in the targeted functions, and more recently, antibiotic tolerance through persistence. In this review, we focus on factors leading to integron rearrangements and gene capture facilitating antibiotic resistance acquisition, maintenance and spread. The role of stress responses, such as the SOS response, is discussed.
Keywords: integron; SOS; sub-MIC; reactive oxygen species; horizontal gene transfer; RpoS; CRP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Baharoglu, Z.; Garriss, G.; Mazel, D. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics 2013, 2, 288-315.

AMA Style

Baharoglu Z, Garriss G, Mazel D. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics. 2013; 2(2):288-315.

Chicago/Turabian Style

Baharoglu, Zeynep; Garriss, Geneviève; Mazel, Didier. 2013. "Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance." Antibiotics 2, no. 2: 288-315.

Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert