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Phenotypic Resistance to Antibiotics
Centro Nacional de Biotecnología, CSIC, Darwin 3, 28049-Madrid, Spain
* Author to whom correspondence should be addressed.
Received: 4 February 2013; in revised form: 22 March 2013 / Accepted: 9 April 2013 / Published: 18 April 2013
Abstract: The development of antibiotic resistance is usually associated with genetic changes, either to the acquisition of resistance genes, or to mutations in elements relevant for the activity of the antibiotic. However, in some situations resistance can be achieved without any genetic alteration; this is called phenotypic resistance. Non-inherited resistance is associated to specific processes such as growth in biofilms, a stationary growth phase or persistence. These situations might occur during infection but they are not usually considered in classical susceptibility tests at the clinical microbiology laboratories. Recent work has also shown that the susceptibility to antibiotics is highly dependent on the bacterial metabolism and that global metabolic regulators can modulate this phenotype. This modulation includes situations in which bacteria can be more resistant or more susceptible to antibiotics. Understanding these processes will thus help in establishing novel therapeutic approaches based on the actual susceptibility shown by bacteria during infection, which might differ from that determined in the laboratory. In this review, we discuss different examples of phenotypic resistance and the mechanisms that regulate the crosstalk between bacterial metabolism and the susceptibility to antibiotics. Finally, information on strategies currently under development for diminishing the phenotypic resistance to antibiotics of bacterial pathogens is presented.
Keywords: phenotypic resistance; biofilm; persistence; bacterial permeability; antibiotic resistance; resistome
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MDPI and ACS Style
Corona, F.; Martinez, J.L. Phenotypic Resistance to Antibiotics. Antibiotics 2013, 2, 237-255.
Corona F, Martinez JL. Phenotypic Resistance to Antibiotics. Antibiotics. 2013; 2(2):237-255.
Corona, Fernando; Martinez, Jose L. 2013. "Phenotypic Resistance to Antibiotics." Antibiotics 2, no. 2: 237-255.