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Antibiotics 2012, 1(1), 25-28; doi:10.3390/antibiotics1010025
Short Note

Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3

1
, 1
, 1
, 2
, 1
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 and 1,2,*
1 Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland 2 School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
* Author to whom correspondence should be addressed.
Received: 29 October 2012 / Revised: 15 November 2012 / Accepted: 15 November 2012 / Published: 20 November 2012
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Abstract

The synthesis of N-heterocyclic carbene (NHC) silver(I) acetate complexes with varying lipophilic benzyl-substituents at the 1 and 3 positions starting from 4,5-diphenylimidazole, opened a new class of antibiotic drug candidates. These NHC-silver(I) acetate derivatives exhibit interesting structural motifs in the solid state and proved to be soluble and stable in biological media. The leading candidate, SBC3, which was known to exhibit good antibacterial activity in preliminary Kirby-Bauer tests, was tested quantitatively using minimum inhibitory concentrations. NHC-silver(I) acetate complexes were found to have MIC values ranging from 20 to 3.13 μg/mL for a variety of Gram-positive, Gram-negative and mycobacteria tested. These values represent good antibiotic activities against potential pathogens when compared to clinically approved antibiotics. Most striking is the fact that SBC3 is active against methicillin-resistant Staphylococcus aureus with a MIC value of 12.5 μg/mL.
Keywords: silver; N-heterocyclic carbene; MRSA silver; N-heterocyclic carbene; MRSA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sharkey, M.A.; O'Gara, J.P.; Gordon, S.V.; Hackenberg, F.; Healy, C.; Paradisi, F.; Patil, S.; Schaible, B.; Tacke, M. Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3. Antibiotics 2012, 1, 25-28.

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