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Biosensors 2018, 8(2), 31; https://doi.org/10.3390/bios8020031

Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application

1
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
School of Public Health, Capital Medical University, Beijing 100069, China
4
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China
*
Author to whom correspondence should be addressed.
Received: 24 January 2018 / Revised: 10 March 2018 / Accepted: 12 March 2018 / Published: 26 March 2018
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Abstract

Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual’s skin permeability, which is closely related to the properties of the stratum corneum (SC). Therefore, measurement of SC impedance has been proposed as an appropriate way for assessing individual skin differences. In order to figure out the current status and research direction of human SC impedance detection, investigations regarding skin impedance measurement have been reviewed in this paper. Future directions are concluded after a review of impedance models, electrodes, measurement methods and systems, and their applications in treatment. It is believed that a well-matched skin impedance model and measurement method will be established for clinical and point-of care applications in the near future. View Full-Text
Keywords: mobile medical care; Non-invasive monitoring; skin impedance; skin permeability; Impedance model mobile medical care; Non-invasive monitoring; skin impedance; skin permeability; Impedance model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lu, F.; Wang, C.; Zhao, R.; Du, L.; Fang, Z.; Guo, X.; Zhao, Z. Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application. Biosensors 2018, 8, 31.

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