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Biosensors 2015, 5(1), 13-24; doi:10.3390/bios5010013

Tracking Traction Force Changes of Single Cells on the Liquid Crystal Surface

1
Biosensor and Bioengineering Laboratory, MiNT-SRC, Universiti Tun Hussein Onn Malaysia, 83000 Batu Pahat, Malaysia
2
School of Engineering, Design and Technology-Medical Engineering, University of Bradford, BD7 1DP Bradford, UK
3
School of Medical Sciences, University of Bradford, BD7 1DP Bradford, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Andrew M. Shaw
Received: 26 August 2014 / Accepted: 2 December 2014 / Published: 5 January 2015
(This article belongs to the Special Issue Label-Free Biosensors: Exploring the Field)
View Full-Text   |   Download PDF [597 KB, uploaded 5 January 2015]   |  

Abstract

Cell migration is a key contributor to wound repair. This study presents findings indicating that the liquid crystal based cell traction force transducer (LCTFT) system can be used in conjunction with a bespoke cell traction force mapping (CTFM) software to monitor cell/surface traction forces from quiescent state in real time. In this study, time-lapse photo microscopy allowed cell induced deformations in liquid crystal coated substrates to be monitored and analyzed. The results indicated that the system could be used to monitor the generation of cell/surface forces in an initially quiescent cell, as it migrated over the culture substrate, via multiple points of contact between the cell and the surface. Future application of this system is the real-time assaying of the pharmacological effects of cytokines on the mechanics of cell migration. View Full-Text
Keywords: liquid crystals; cell traction force transducer; keratinocytes; cell force mapping; cell translocation liquid crystals; cell traction force transducer; keratinocytes; cell force mapping; cell translocation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Soon, C.F.; Tee, K.S.; Youseffi, M.; Denyer, M.C.T. Tracking Traction Force Changes of Single Cells on the Liquid Crystal Surface. Biosensors 2015, 5, 13-24.

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