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Biosensors 2014, 4(2), 161-171; doi:10.3390/bios4020161

Polymerization Parameters Influencing the QCM Response Characteristics of BSA MIP

Department of Analytical Chemistry, Faculty for Chemistry, University of Vienna, Währinger Straße 38, A-1090 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 8 April 2014 / Revised: 23 May 2014 / Accepted: 9 June 2014 / Published: 16 June 2014
(This article belongs to the Special Issue Piezoelectric Biosensors)
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Designing Molecularly Imprinted Polymers for sensing proteins is still a somewhat empirical process due to the inherent complexity of protein imprinting. Based on Bovine Serum Albumin as a model analyte, we explored the influence of a range of experimental parameters on the final sensor responses. The optimized polymer contains 70% cross linker. Lower amounts lead to higher sensitivity, but also sensor response times substantially increase (to up to 10 h) at constant imprinting effect (signal ratio MIP/NIP on quartz crystal microbalance—QCM). However, by shifting the polymer properties to more hydrophilic by replacing methacrylic acid by acrylic acid, part of the decreased sensitivity can be recovered leading to appreciable sensor responses. Changing polymer morphology by bulk imprinting and nanoparticle approaches has much lower influence on sensitivity.
Keywords: molecular imprinted polymer; protein imprinting; polymer optimization; QCM molecular imprinted polymer; protein imprinting; polymer optimization; QCM
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Phan, N.V.H.; Sussitz, H.F.; Lieberzeit, P.A. Polymerization Parameters Influencing the QCM Response Characteristics of BSA MIP. Biosensors 2014, 4, 161-171.

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