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Biosensors 2014, 4(2), 137-149; doi:10.3390/bios4020137
Article

A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety

1,2,†
, 1,2,†
, 1,2
 and 1,2,3,*
1 Bioorganic & Biophysical Chemistry Laboratory, Linnæus University Centre for Biomaterials Chemistry, Linnæus University, SE-39182 Kalmar, Sweden 2 Department of Chemistry & Biomedical Sciences, Linnæus University, SE-39182 Kalmar, Sweden 3 Department of Chemistry—BMC, Uppsala University, Box 576, SE-75123 Uppsala, Sweden These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 March 2014 / Revised: 11 April 2014 / Accepted: 23 April 2014 / Published: 29 April 2014
(This article belongs to the Special Issue Piezoelectric Biosensors)
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Abstract

Phage display screening of a surface-immobilized adenine derivative led to the identification of a heptameric peptide with selectivity for adenine as demonstrated through quartz crystal microbalance (QCM) studies. The peptide demonstrated a concentration dependent affinity for an adeninyl moiety decorated surface (KD of 968 ± 53.3 μM), which highlights the power of piezoelectric sensing in the study of weak interactions.
Keywords: phage display; piezoelectric sensor; QCM; adenine; peptide; molecular recognition phage display; piezoelectric sensor; QCM; adenine; peptide; molecular recognition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Elmlund, L.; Söderberg, P.; Suriyanarayanan, S.; Nicholls, I.A. A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety. Biosensors 2014, 4, 137-149.

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