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Biosensors 2014, 4(2), 137-149; doi:10.3390/bios4020137
Article

A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety

1,2,†
, 1,2,†
, 1,2
 and 1,2,3,*
Received: 4 March 2014; in revised form: 11 April 2014 / Accepted: 23 April 2014 / Published: 29 April 2014
(This article belongs to the Special Issue Piezoelectric Biosensors)
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Abstract: Phage display screening of a surface-immobilized adenine derivative led to the identification of a heptameric peptide with selectivity for adenine as demonstrated through quartz crystal microbalance (QCM) studies. The peptide demonstrated a concentration dependent affinity for an adeninyl moiety decorated surface (KD of 968 ± 53.3 μM), which highlights the power of piezoelectric sensing in the study of weak interactions.
Keywords: phage display; piezoelectric sensor; QCM; adenine; peptide; molecular recognition phage display; piezoelectric sensor; QCM; adenine; peptide; molecular recognition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Elmlund, L.; Söderberg, P.; Suriyanarayanan, S.; Nicholls, I.A. A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety. Biosensors 2014, 4, 137-149.

AMA Style

Elmlund L, Söderberg P, Suriyanarayanan S, Nicholls IA. A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety. Biosensors. 2014; 4(2):137-149.

Chicago/Turabian Style

Elmlund, Louise; Söderberg, Pernilla; Suriyanarayanan, Subramanian; Nicholls, Ian A. 2014. "A Phage Display Screening Derived Peptide with Affinity for the Adeninyl Moiety." Biosensors 4, no. 2: 137-149.

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