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Nanomaterials 2018, 8(4), 252; https://doi.org/10.3390/nano8040252

Shape-Controlled Synthesis of Au Nanostructures Using EDTA Tetrasodium Salt and Their Photothermal Therapy Applications

1
Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200003, Israel
2
School of Advanced Materials Engineering, Kookmin University, Seoul 02707, Korea
3
Center for Nanoparticle Research, Institute for Basic Science, and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-742, Korea
4
School of Chemical Engineering, Chonnam National University, Gwangju 61186, Korea
5
Graduate School of Convergence Science and Technology & Advanced Institutes of Convergence Technology, Seoul National University, Suwon 16229, Korea
*
Authors to whom correspondence should be addressed.
Received: 27 March 2018 / Revised: 15 April 2018 / Accepted: 16 April 2018 / Published: 18 April 2018
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Abstract

Tuning the optical properties of Au nanostructures is of paramount importance for scientific interest and has a wide variety of applications. Since the surface plasmon resonance properties of Au nanostructures can be readily adjusted by changing their shape, many approaches for preparing Au nanostructures with various shapes have been reported to date. However, complicated steps or the addition of several reagents would be required to achieve shape control of Au nanostructures. The present work describes a facile and effective shape-controlled synthesis of Au nanostructures and their photothermal therapy applications. The preparation procedure involved the reaction of HAuCl4 and ethylenediaminetetraacetic acid (EDTA) tetrasodium salt, which acted as a reducing agent and ligand, at room temperature without the need for any toxic reagent or additives. The morphology control from spheres to branched forms and nanowire networks was easily achieved by varying the EDTA concentration. Detailed investigations revealed that the four carboxylic groups of the EDTA tetrasodium salt are essential for effective growth and stabilization. The produced Au nanowire networks exhibited a broad absorption band in the near-infrared (NIR) region, thereby showing efficient cancer therapeutic performance by inducing the selective photothermal destruction of cancerous glioblastoma cells (U87MG) under NIR irradiation. View Full-Text
Keywords: gold; nanostructure; EDTA tetrasodium salt; photothermal therapy gold; nanostructure; EDTA tetrasodium salt; photothermal therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jang, Y.; Lee, N.; Kim, J.H.; Park, Y.I.; Piao, Y. Shape-Controlled Synthesis of Au Nanostructures Using EDTA Tetrasodium Salt and Their Photothermal Therapy Applications. Nanomaterials 2018, 8, 252.

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