Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers
Abstract
:1. Introduction
2. The Basics of Polymer-Based Nanocarriers
2.1. Ingredients of Nanocarriers
2.2. Core-Shell Structured Nanocarriers
2.2.1. Typical Core-Shell Structured Nanocarriers
2.2.2. Recent Advances of Novel Core-Shell Structured Nanocarriers
2.3. Frame-Coat Structured Nanocarriers
2.3.1. Various Frames
2.3.2. Preparation of Frame-Coat Structured Nanocarriers
2.4. Navigation of Nanocarriers to Tumors
2.5. A New Trend: Preventions to Premature Leak of Drug
3. Combination of Chemotherapy with Photothermal Therapy via Nanocarriers
3.1. The Basics of Photothermal Therapy
3.2. The Interactions of Chemotherapy and Photothermal Therapy
3.3. The Ways to Fight Against Multi-Drug Resistance
3.4. Light-Controlled Drug Release
4. The Therapeutic Effects of Combinational Therapy with Nanocarriers
4.1. In Vitro Cell Experiments
4.2. In Vivo Experiments
4.3. Fighting Against Recurrence and Metastasis
4.4. Triple-Modality Therapies
4.5. Pending Clinical Trials
5. Problems, Hurdles and Challenges
6. Discussions and Suggestions
7. Conclusions and Outlook
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Photothermal Material | Drug(s) | Polymer | Targeting Ligand | Reference |
---|---|---|---|---|
IR780 | AMD3100 | PC, MCT and trilaurin | AMD3100 | [3] |
ICG | DOX | Carboxyl-terminated pluronic F68 and polyethyleneimine-coated perfluorocarbon | HER2 antibody | [9] |
Fe3O4 | DOX | PMMA and PMMA-co-DMAEMA-co-DVB-co-PEG360-co-AA-co-DS | None | [14] |
IR780 | SN38 | IR780-mPEG and IR780-mPEG-cRGD | cRGD | [45] |
RGO | Resveratrol | Folate acid-terminated PEG-phospholipid | Folate acid | [21] |
Au-S nanorod | DOX, NaHCO3 and Salicylic acid | PVA, PLGA and TPGS | None | [23] |
AuNS | Resveratrol | Resveratrol-binding lipid and CTS | None | [24] |
CuS and MoS2 | DOX | Aptamer, NH2-(SH)-PEG | None | [60] |
PDA | DOX | PDA and PLGA | None | [26] |
OA-PB NP | DOX | DSPE-PEG 2000 | None | [27] |
BCNP | Curcumin | TPGS | None | [48] |
PPy NP | Rapamycin | DPPC, cholesterol, CHEMS and DSPE-PEG2000-Maleimide | Trastuzumab | [49] |
ICG | Wedelolactone | Soybean phosphatidylcholine, Cholesterol and PEG-2000 | None | [50] |
NGO | DOX and Rapamycin | PEGylated lipid | None | [51] |
ICG | DOX | PEG-PLGA | HER2 antibody | [61] |
RGO | DOX | PVA | Lactoferrin | [64] |
HMPB | DOX | Red blood cell membrane | None | [76] |
Diketopyrrolopyrrole-based polymers | DOX | TPGS-CHO copolymers | None | [80] |
CuS | DTX | Povidone and chitosan | Folic acid | [81] |
OA-CuS-NP | DOX | Chitosan | None | [82] |
ICG | DOX | PLGA and NAcHis-TPGS | None | [83] |
Graphene nanosponge | DTX and Perfluorohexane | DOPE and DSPE-PEG2000-NH2 | Lactoferrin | [84] |
BCNP | DOX | Tween 80 | None | [85] |
Nanogold and Fe3O4 | DOX | PSMA | None | [86] |
Fe3O4 | DOX | poly(N-isopropylacrylamide)-co-1-Vinyl-2-pyrrolidone | None | [87] |
ICG | DOX | PPE-Chol1-HA | Hyaluronic acid | [88] |
Porphyrin-phospholipid (PoP) | DOX | DOTAP and PoP | None | [89] |
PDA NP | Bortezomib and DOX | pNIPAAm-co-pAAm | None | [90] |
SPION (Fe2O3) | DOX | -PLGA-PEG-PLGA-urethane-SS- | Folic acid | [91] |
Fe3O4 | DOX | mPEG-g-PDAEAIM | None | [92] |
Frame | Photothermal Material | Drug(s) | Polymer | Targeting Ligand | Reference |
---|---|---|---|---|---|
Monoolein | GO | DTX | CTS-PEG | GO | [11] |
Si/C NP | C in Si/C NPs | DOX | PEG | None | [39] |
MWNT | MWNT | DOX | CTS | Transactivator of transcription | [41] |
PdNP | Gold | DOX | ZIF-8 | None | [22] |
GO@Gd | GO | DOX | PEG-2000 | Folic acid | [79] |
PDA | PDA | DOX and SN-38 | PEG | None | [28] |
SWNT | SWNT | DOX | PEG | None | [29] |
SiNP | Polyaniline | DOX | Polyaniline | None | [30,35] |
Silica | Palladium phthalocyanine | PTX | Pluroic F108 | None | [31] |
ZnO nanosheet | ZnO NS | DOX | PEG | Folic acid | [35] |
NGO | NGO and ICG | PTX | PEG | None | [36] |
MCN | MCN | DOX | PEG-PCDA | None | [37] |
PDA NP | PDA NP | CP | PEG | None | [47] |
Fluorinated GO | Fe3O4 | DOX | FGO | None | [59] |
GO | GO | Mitoxantrone | Hyaluronic acid and Pluronic | Hyaluronic acid | [63] |
MWNT@PPy@Au shell | MWNT@PPy@Au shell | DOX | FA-PEG-SH | Folic acid | [94] |
PPy@Mil-100(Fe) | PPy | DOX | PPy | None | [73] |
PPy | PPy | DOX | Hyaluronic acid | Hyaluronic acid | [72] |
PNA | PPy | DOX | Chitosan (CTS) | None | [70] |
PPy@DSN | PPy | DOX | PEG | None | [71] |
ZrO2 | (PPy) | DOX | PPy | None | [69] |
NGO | NGO and GNS | DOX | PDA-PEG | None | [66] |
MPDA | MPDA | DOX | TPGS | None | [67] |
RGO | PDA | Ara or HCPT | PDA | None | [68] |
PEI and DNA | AuNR | DOX and PND | PEI and DNA | Biotin | [74] |
GNP | GNP | DOX | Hairpin-like aptamer AS1411 | AS1411 | [75] |
AuNC with tetradecanol | AuNC | DOX | Biotin-PEG-PCDA | Biotin | [77] |
AuNC with tetradecanol | AuNC and ICG | DOX | PEG | Biotin | [78] |
HPMO | GNR | PTX | Mesenchymal stem cells (MSCs) | MSCs per se | [93] |
NGO | NGO | DOX | PEG | Octreotide | [95] |
SWCNT | CNT | DOX | CS-OA and PNIPAAm | None | [96] |
RGO | rGO and Bi2S3 | DOX | PVP | None | [97] |
Nano graphene | Nano graphene | Curcumin | Hyperbranched polyglycerol | None | [98] |
SiO2@Au | Gold and GO | DTX | HS-PEG-NH2 and GO | None | [99] |
Gold nanorod (AuNR) | AuNR | DOX and TMPyP4 | DNA and/or AS1411 | None | [100] |
AuNC | AuNC | DOX | Hyaluronic acid and PEG | A54 peptide | [101] |
HAuNs | HAuNs | DOX and Ce6 | p(OEGMA-co-MEMA) | None | [102] |
AuNS | AuNS | DOX | Hyaluronic acid (HA) | HA, Cationic peptide R8 and mitochondria-targeting peptide TPP-KLA | [103] |
PPy@Mil-100(Fe) | PPy | DOX | PPy | None | [104] |
OA-Cu2Te NC | Cu2Te | DOX | DSPE-PEG2000 | None | [105] |
MoO3−x HNS | MoO3−x HNS | Camptothecin | PEG | None | [106] |
PB-NP | PB-NP | Artemisinin | Mil-100(Fe) | No | [107] |
CaCO3 | AuNR | DOX, 17-AAG Afatinib HER-2 antibody Amylase | Phospholipid, POPC Acetalated dextran | None | [108] |
G (a nano gel) | CuS | DOX | G | None | [109] |
CTS | Fe3O4 and ICG | DOX | CTS | None | [110] |
PNIPAM, SBMA, MAA and BAC | ICG | DOX | The same as the frame | None | [111] |
Fe3O4 | Fe3O4 | DOX | CMCTS | None | [112] |
Fe3O4@mSiO2 | Fe3O4 and CuS | DOX | PEG | Folic acid | [113] |
MSN | AuNR | DOX | Hyaluronic acid | None | [114] |
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Share and Cite
Yan, G.; Li, A.; Zhang, A.; Sun, Y.; Liu, J. Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers. Nanomaterials 2018, 8, 85. https://doi.org/10.3390/nano8020085
Yan G, Li A, Zhang A, Sun Y, Liu J. Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers. Nanomaterials. 2018; 8(2):85. https://doi.org/10.3390/nano8020085
Chicago/Turabian StyleYan, Guowen, Aihua Li, Aitang Zhang, Yong Sun, and Jingquan Liu. 2018. "Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers" Nanomaterials 8, no. 2: 85. https://doi.org/10.3390/nano8020085