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Nanomaterials 2017, 7(9), 274; doi:10.3390/nano7090274

Biocompatibility of Titania Nanotube Coatings Enriched with Silver Nanograins by Chemical Vapor Deposition

Faculty of Chemistry, Nicolaus Copernicus University in Toruń, ul. Gagarina 7, 87-100 Toruń, Poland
Nano-implant Ltd., NIP 9562314777, Gagarina 5, 87-100 Toruń, Poland
Faculty of Biology and Environment Protection, Nicolaus Copernicus University in Toruń, ul. Lwowska 1, 87-100 Toruń, Poland
Faculty of Biology and Environmental Protection, University of Lódź, ul. S. Banacha 12/16, 90-237 Łódź, Poland
August Chełkowski Institute of Physics, University of Silesia, ul. Uniwersytecka 4, 40-007 Katowice, Poland
Di.S.C.O.—Sezione di Biochimica, Biologia e Fisica, Università Politecnica delle Marche, 60131 Ancona, Italy
Author to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 9 September 2017 / Accepted: 12 September 2017 / Published: 15 September 2017
(This article belongs to the Special Issue Nanoparticles in Immunology)
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Bioactivity investigations of titania nanotube (TNT) coatings enriched with silver nanograins (TNT/Ag) have been carried out. TNT/Ag nanocomposite materials were produced by combining the electrochemical anodization and chemical vapor deposition methods. Fabricated coatings were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and Raman spectroscopy. The release effect of silver ions from TNT/Ag composites immersed in bodily fluids, has been studied using inductively coupled plasma mass spectrometry (ICP-MS). The metabolic activity assay (MTT) was applied to determine the L929 murine fibroblasts adhesion and proliferation on the surface of TNT/Ag coatings. Moreover, the results of immunoassays (using peripheral blood mononuclear cells—PBMCs isolated from rats) allowed the estimation of the immunological activity of TNT/Ag surface materials. Antibacterial activity of TNT/Ag coatings with different morphological and structural features was estimated against two Staphylococcus aureus strains (ATCC 29213 and H9). The TNT/Ag nanocomposite layers produced revealed a good biocompatibility promoting the fibroblast adhesion and proliferation. A desirable anti-biofilm activity against the S. aureus reference strain was mainly noticed for these TiO2 nanotube coatings, which contain dispersed Ag nanograins deposited on their surface. View Full-Text
Keywords: titania nanotube coatings; silver nanograins; surface morphology; biointegration properties; immunological activity titania nanotube coatings; silver nanograins; surface morphology; biointegration properties; immunological activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Piszczek, P.; Lewandowska, Ż.; Radtke, A.; Jędrzejewski, T.; Kozak, W.; Sadowska, B.; Szubka, M.; Talik, E.; Fiori, F. Biocompatibility of Titania Nanotube Coatings Enriched with Silver Nanograins by Chemical Vapor Deposition. Nanomaterials 2017, 7, 274.

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