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Nanomaterials 2017, 7(9), 244; doi:10.3390/nano7090244

Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System

1
Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Serdang 43400, Selangor, Malaysia
2
Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Serdang 43400, Selangor, Malaysia
3
Department of Human Anatomy, Faculty of Medicine and Health Sciences, Serdang 43400, Selangor, Malaysia
4
Department of Cell & Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Serdang 43400, Selangor, Malaysia
5
Centre for Diagnostic and Nuclear Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
Received: 16 July 2017 / Revised: 18 August 2017 / Accepted: 25 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug delivery)
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Abstract

We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment. View Full-Text
Keywords: Zn/Al LDH; gallic acid; therapeutic; diagnostic; theranostic Zn/Al LDH; gallic acid; therapeutic; diagnostic; theranostic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sani Usman, M.; Hussein, M.Z.; Fakurazi, S.; Masarudin, M.J.; Ahmad Saad, F.F. Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System. Nanomaterials 2017, 7, 244.

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