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Nanomaterials 2017, 7(7), 155; doi:10.3390/nano7070155

Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs

1
Departament de Física, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Cerdanyola del Vallès, Spain
2
Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Cerdanyola del Vallès, Spain
3
Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, E-08010 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Received: 6 June 2017 / Revised: 21 June 2017 / Accepted: 22 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue Polymer Nanocomposites)
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Abstract

Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms. View Full-Text
Keywords: biodegradable material; porous membrane; drug delivery; hybrid material biodegradable material; porous membrane; drug delivery; hybrid material
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Fornell, J.; Soriano, J.; Guerrero, M.; Sirvent, J.D.; Ferran-Marqués, M.; Ibáñez, E.; Barrios, L.; Baró, M.D.; Suriñach, S.; Nogués, C.; Sort, J.; Pellicer, E. Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs. Nanomaterials 2017, 7, 155.

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