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Nanomaterials 2017, 7(6), 127; doi:10.3390/nano7060127

Heteromer Nanostars by Spontaneous Self-Assembly

1
Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO 65409, USA
2
Department of Biological Sciences, Missouri University of Science and Technology, 143 Schrenk Hall, 400 W. 11th St., Rolla, MO 65409, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giuliana Gorrasi
Received: 23 April 2017 / Revised: 17 May 2017 / Accepted: 23 May 2017 / Published: 31 May 2017
(This article belongs to the Special Issue Polymer Nanocomposites)
View Full-Text   |   Download PDF [2913 KB, uploaded 31 May 2017]   |  

Abstract

Heteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), silver nitrate, and tetrakis(hydroxymethyl)phosphonium chloride (THPC). Mixing these reagents followed by UV irradiation successfully produced heteromer nanostars containing a number of arm chains attached to a single core with a high yield. The release of THPC from heteromer nanostars was tested for its potential use for breast cancer treatment. The nanostars present a unique geometrical design exhibiting a significant intracellular uptake by breast cancer cells but low cytotoxicity that potentiates its efficacy as drug carriers. View Full-Text
Keywords: nanostar; polylactide-co-glycolic acid (PLGA); star shape; tetrakis (hydroxylmethyl) phosphonium chloride (THPC) nanostar; polylactide-co-glycolic acid (PLGA); star shape; tetrakis (hydroxylmethyl) phosphonium chloride (THPC)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Brocker, C.; Kim, H.; Smith, D.; Barua, S. Heteromer Nanostars by Spontaneous Self-Assembly. Nanomaterials 2017, 7, 127.

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