Heteromer Nanostars by Spontaneous Self-Assembly
AbstractHeteromer star-shaped nanoparticles have the potential to carry out therapeutic agents, improve intracellular uptake, and safely release drugs after prolonged periods of residence at the diseased site. A one-step seed mediation process was employed using polylactide-co-glycolic acid (PLGA), polyvinyl alcohol (PVA), silver nitrate, and tetrakis(hydroxymethyl)phosphonium chloride (THPC). Mixing these reagents followed by UV irradiation successfully produced heteromer nanostars containing a number of arm chains attached to a single core with a high yield. The release of THPC from heteromer nanostars was tested for its potential use for breast cancer treatment. The nanostars present a unique geometrical design exhibiting a significant intracellular uptake by breast cancer cells but low cytotoxicity that potentiates its efficacy as drug carriers. View Full-Text
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Brocker, C.; Kim, H.; Smith, D.; Barua, S. Heteromer Nanostars by Spontaneous Self-Assembly. Nanomaterials 2017, 7, 127.
Brocker C, Kim H, Smith D, Barua S. Heteromer Nanostars by Spontaneous Self-Assembly. Nanomaterials. 2017; 7(6):127.Chicago/Turabian Style
Brocker, Caitlin; Kim, Hannah; Smith, Daniel; Barua, Sutapa. 2017. "Heteromer Nanostars by Spontaneous Self-Assembly." Nanomaterials 7, no. 6: 127.
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