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Nanomaterials 2017, 7(6), 132; doi:10.3390/nano7060132

Glutathione-Mediated Cu(I)/Cu(II) Complexes: Valence-Dependent Effects on Clearance and In Vivo Imaging Application

1
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2
School of Environmental, Physical and Applied Sciences, University of Central Missouri, Warrensburg, MO 64093, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Yurii Gun’ko
Received: 6 May 2017 / Revised: 17 May 2017 / Accepted: 20 May 2017 / Published: 1 June 2017
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Abstract

Contrast imaging agents need to be cleared in a reasonable time (less than 72 h), so it is quite urgent to understand the structure, biocompatibility, and metabolism features of imaging agents. In this work, luminescent Cu(I)-GSH complex and their derivative oxidized Cu(II)-GSSG complex have been easily synthesized. Through systematically probing the renal clearance and biodistribution of the as-prepared copper complexes, we found that Cu(I)-GSH complex revealed much more efficient renal clearance and remarkably lower liver accumulation than that of their oxidation states, which could be due to strong protein binding of partial forms of Cu(II)-GSSG complex. Besides, we also attempted to incorporate radioactive copper-64 into Cu(I)-GSH complex for the synthesis of radioactive contrast agent. Indeed, the as-prepared radioactive Cu(I)-GSH complex also showed consistent high efficiency renal excretion, allowing them to be potential PET imaging agents in clinical translation. View Full-Text
Keywords: renal clearable; luminescence; copper complexes; biodistribution; PET imaging renal clearable; luminescence; copper complexes; biodistribution; PET imaging
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Yin, S.-N.; Liu, Y.; Zhou, C.; Yang, S. Glutathione-Mediated Cu(I)/Cu(II) Complexes: Valence-Dependent Effects on Clearance and In Vivo Imaging Application. Nanomaterials 2017, 7, 132.

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