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Nanomaterials 2017, 7(4), 83; doi:10.3390/nano7040083

Investigating the Origins of Toxic Response in TiO2 Nanoparticle-Treated Cells

Department of Genetics and Bioengineering, Yeditepe University, 34755 Atasehir, Istanbul, Turkey
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Academic Editor: Thomas Nann
Received: 24 February 2017 / Revised: 3 April 2017 / Accepted: 5 April 2017 / Published: 11 April 2017
(This article belongs to the Special Issue Nanoparticle-Mediated Cell and Tissue Stimulation)
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Abstract

Titanium dioxide nanoparticles (TiO2 NPs) are widely used in sunscreens, cosmetics and body implants, and this raises toxicity concerns. Although a large number of reports claim that they are safe to use, others claim that they induce reactive oxygen species formation and can be carcinogenic. In this study, the origins of toxic response to TiO2 NPs were investigated by using Surface-enhanced Raman spectroscopy (SERS) which provides multidimensional information on the cellular dynamics at single cell level without any requirement for cell fixation. Three cell lines of vein (HUVEC), lung carcinoma (A549) and skin (L929) origin were tested for their toxic response upon exposure to 20, 40, 80 and 160 µg/mL anatase-TiO2 NPs for 24 h. It was demonstrated that the level of toxic response is both cell line and dose-dependent. L929 fibroblasts were the most resistant cell line to oxidative stress whereas in HUVEC and A549, cell lines collagen and lipid deformation were observed, respectively. View Full-Text
Keywords: titanium dioxide nanoparticles; TiO2 NPs; nanotoxicity; Surface-enhanced Raman scattering; SERS; cytotoxicity titanium dioxide nanoparticles; TiO2 NPs; nanotoxicity; Surface-enhanced Raman scattering; SERS; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kuku, G.; Culha, M. Investigating the Origins of Toxic Response in TiO2 Nanoparticle-Treated Cells. Nanomaterials 2017, 7, 83.

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