Next Article in Journal
Stepwise Splitting Growth and Pseudocapacitive Properties of Hierarchical Three-Dimensional Co3O4 Nanobooks
Next Article in Special Issue
Investigating the Origins of Toxic Response in TiO2 Nanoparticle-Treated Cells
Previous Article in Journal
Cellular Response to Titanium Dioxide Nanoparticles in Intestinal Epithelial Caco-2 Cells is Dependent on Endocytosis-Associated Structures and Mediated by EGFR
Previous Article in Special Issue
Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Nanomaterials 2017, 7(4), 80;

Cytotoxicity of ZnO Nanowire Arrays on Excitable Cells

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA
Department of Electrical and Computer Engineering, The Ohio State University, Columbus, OH 43210, USA
Department of Food, Agricultural and Biological Engineering, The Ohio State University, Columbus, OH 43210, USA
Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA
Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
These authors contributed equally to the work.
Author to whom correspondence should be addressed.
Academic Editor: Gianni Ciofani
Received: 15 February 2017 / Revised: 29 March 2017 / Accepted: 30 March 2017 / Published: 7 April 2017
(This article belongs to the Special Issue Nanoparticle-Mediated Cell and Tissue Stimulation)
View Full-Text   |   Download PDF [3242 KB, uploaded 7 April 2017]   |  


Zinc oxide (ZnO) nanowires have been widely studied for their applications in electronics, optics, and catalysts. Their semiconducting, piezoelectric, fluorescent, and antibacterial properties have also attracted broad interest in their biomedical applications. Thus, it is imperative to evaluate the biosafety of ZnO nanowires and their biological effects. In this study, the cellular level biological effects of ZnO nanowire arrays are specifically tested on three types of excitable cells, including NG108-15 neuronal cell line, HL-1 cardiac muscle cell line, and neonatal rat cardiomyocytes. Vertically aligned and densely packed ZnO nanowire arrays are synthesized using a solution-based method and used as a substrate for cell culture. The metabolism levels of all three types of cells cultured on ZnO nanowire arrays are studied using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays of a full factorial design. Under the studied settings, the results show statistically significant inhibitory effects of ZnO nanowire arrays on the metabolism of NG108-15 and HL-1 cells in comparison to gold, glass, and polystyrene substrates, and on the metabolism of cardiomyocytes in comparison to gold substrate. View Full-Text
Keywords: ZnO nanowire arrays; cytotoxicity; excitable cells ZnO nanowire arrays; cytotoxicity; excitable cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, Y.; Wu, Y.; Quadri, F.; Prox, J.D.; Guo, L. Cytotoxicity of ZnO Nanowire Arrays on Excitable Cells. Nanomaterials 2017, 7, 80.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top