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Nanomaterials 2017, 7(4), 82; doi:10.3390/nano7040082

An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy

1
Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Avenida Presidente Antônio Carlos, 6627 Pampulha, Belo Horizonte 31270-901, MG, Brazil
2
Departamento de Bioquímica e Imunologia—ICB—UFMG, Avenida Presidente Antônio Carlos, 6627 Pampulha, Belo Horizonte 31270-901, MG, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Gianni Ciofani
Received: 15 February 2017 / Revised: 3 April 2017 / Accepted: 4 April 2017 / Published: 12 April 2017
(This article belongs to the Special Issue Nanoparticle-Mediated Cell and Tissue Stimulation)
View Full-Text   |   Download PDF [3768 KB, uploaded 12 April 2017]   |  

Abstract

Currently, nanostructured compounds have been standing out for their optical, mechanical, and chemical features and for the possibilities of manipulation and regulation of complex biological processes. One of these compounds is boron nitride nanotubes (BNNTs), which are a nanostructured material analog to carbon nanotubes, but formed of nitrogen and boron atoms. BNNTs present high thermal stability along with high chemical inertia. Among biological applications, its biocompatibility, cellular uptake, and functionalization potential can be highlighted, in addition to its eased utilization due to its nanometric size and tumor cell internalization. When it comes to new forms of therapy, we can draw attention to boron neutron capture therapy (BNCT), an experimental radiotherapy characterized by a boron-10 isotope carrier inside the target and a thermal neutron beam focused on it. The activation of the boron-10 atom by a neutron generates a lithium atom, a gamma ray, and an alpha particle, which can be used to destroy tumor tissues. The aim of this work was to use BNNTs as a boron-10 carrier for BNCT and to demonstrate its potential. The nanomaterial was characterized through XRD, FTIR, and SEM. The WST-8 assay was performed to confirm the cell viability of BNNTs. The cells treated with BNNTs were irradiated with the neutron beam of a Triga reactor, and the apoptosis caused by the activation of the BNNTs was measured with a calcein AM/propidium iodide test. The results demonstrate that this nanomaterial is a promising candidate for cancer therapy through BNCT. View Full-Text
Keywords: boron nitride nanotubes; BNNTs; bioapplications; boron neutron capture therapy; BNCT; cancer therapy boron nitride nanotubes; BNNTs; bioapplications; boron neutron capture therapy; BNCT; cancer therapy
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MDPI and ACS Style

Ferreira, T.H.; Miranda, M.C.; Rocha, Z.; Leal, A.S.; Gomes, D.A.; Sousa, E.M.B. An Assessment of the Potential Use of BNNTs for Boron Neutron Capture Therapy. Nanomaterials 2017, 7, 82.

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