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Nanomaterials 2017, 7(4), 92;

Gold Nanoparticles for Modulating Neuronal Behavior

LP2N-Institut d’Optique & CNRS, University of Bordeaux, 33400 Talence, France
ARC Training Centre in Biodevices, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, P.O. Box 218, Victoria 3122, Australia
Author to whom correspondence should be addressed.
Academic Editor: Gianni Ciofani
Received: 30 March 2017 / Revised: 19 April 2017 / Accepted: 19 April 2017 / Published: 24 April 2017
(This article belongs to the Special Issue Nanoparticle-Mediated Cell and Tissue Stimulation)
View Full-Text   |   Download PDF [13284 KB, uploaded 24 April 2017]   |  


Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface. This review provides a critical overview of the photothermal and photomechanical properties of chemically functionalized gold nanoparticles that have been exploited to trigger a range of biological responses in neuronal tissues, including modulation of electrical activity and nerve regeneration. The prospects and challenges for further development are also discussed. View Full-Text
Keywords: gold nanoparticles; plasmonics; photothermal effects; neuronal cell behavior gold nanoparticles; plasmonics; photothermal effects; neuronal cell behavior

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Paviolo, C.; Stoddart, P.R. Gold Nanoparticles for Modulating Neuronal Behavior. Nanomaterials 2017, 7, 92.

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