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Nanomaterials 2017, 7(4), 75;

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

Dipartimento di Chimica, Università Degli Studi di Bari “Aldo Moro”, via E. Orabona 4, Bari (BA) 70126, Italy
Author to whom correspondence should be addressed.
Academic Editor: John HT Luong
Received: 13 February 2017 / Revised: 24 March 2017 / Accepted: 28 March 2017 / Published: 2 April 2017
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
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Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques. View Full-Text
Keywords: SALDI; nanomaterial; ion desorption efficiency; internal energy transfer; benzylpyridinium; laser-nanoparticle interaction SALDI; nanomaterial; ion desorption efficiency; internal energy transfer; benzylpyridinium; laser-nanoparticle interaction

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Picca, R.A.; Calvano, C.D.; Cioffi, N.; Palmisano, F. Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review. Nanomaterials 2017, 7, 75.

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