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Special Issue "Nanomaterials for Mass Spectrometry Applications"

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A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (30 June 2017)

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Special Issue Editors

Guest Editor Prof. Dr. Nicola Cioffi Università degli Studi di Bari Aldo Moro, Dipartimento di Chimica, 4 via Orabona, I-70126 Bari, Italy Website1 \| Website2 \| E-Mail Phone: +39-080-5442020 Fax: +390805442026 Interests: analytical chemistry; surface spectroscopy and nanomaterials for life sciences; including: antibacterial nanomaterials; sensors; mass spectrometry; green chemistry; catalysis
Guest Editor Dr. Rosaria Anna Picca Chemistry Department, University of Bari “Aldo Moro”, Campus Universitario, Bari 70126, Italy Website \| E-Mail Phone: +39-080-5442030 Fax: +39-080-5442026 Interests: nanomaterials; nanoantimicrobials; laser desorption/ionization mass spectrometry; X-ray photoelectron spectroscopy (XPS); thin films; sensors; analytical chemistry
Guest Editor Prof. Dr. Francesco Palmisano Dipartimento di Chimica, Campus Universitario, Bari 70126, Italy Website \| E-Mail Phone: +39-080-5442016 Interests: analytical chemistry; mass spectrometry applied to –omic science

Special Issue Information

Dear Colleagues,

This Special Issue is focused on both fundamental and application aspects of the use of Nanomaterials in Mass Spectrometry.

Topics include:

Nanomaterials as extraction tools/signal enhancers in mass spectrometry analysis of low-abundance species
Development of MS sub-techniques based on nanomaterials, such as SALDI-MS, NALDI-MS, SELDI-MS, etc.
Development of MS analysis protocols based on nanomaterials
Imaging MALDI-ToF-MS based on nanoparticles as labels/markers
Fundamentals of phenomena, such as nanoparticle ionization events, nanomaterial promotion of analyte’s ionization/desorption processes, nanoparticle-tissue interactions in MS applications, etc.

Studies specifically dealing with nanomaterials’ MS applications (in Food Science, Medicine, Omics fields, Materials Science, etc.) are also welcome.

Prof. Dr. Nicola Cioffi
Dr. Rosaria Anna Picca
Prof. Dr. Francesco Palmisano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Nanomaterials
Mass Spectrometry
NALDI-MS
SALDI-MS
SELDI-MS
Imaging-MALDI-ToF-MS

Published Papers (3 papers)

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Research

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Open AccessArticle A Nanostructured Matrices Assessment to Study Drug Distribution in Solid Tumor Tissues by Mass Spectrometry Imaging

by Silvia Giordano, Valentina Pifferi, Lavinia Morosi, Melinda Morelli, Luigi Falciola, Giuseppe Cappelletti, Sonja Visentin, Simonetta A. Licandro, Roberta Frapolli, Massimo Zucchetti, Roberta Pastorelli, Laura Brunelli, Maurizio D’Incalci and Enrico Davoli

Nanomaterials 2017, 7(3), 71; doi:10.3390/nano7030071

Received: 6 February 2017 / Revised: 13 March 2017 / Accepted: 16 March 2017 / Published: 21 March 2017

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Abstract

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The imaging of drugs inside tissues is pivotal in oncology to assess whether a drug reaches all cells in an adequate enough concentration to eradicate the tumor. Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging (MALDI-MSI) is one of the most promising imaging techniques that enables the simultaneous visualization of multiple compounds inside tissues. The choice of a suitable matrix constitutes a critical aspect during the development of a MALDI-MSI protocol since the matrix ionization efficiency changes depending on the analyte structure and its physico-chemical properties. The objective of this study is the improvement of the MALDI-MSI technique in the field of pharmacology; developing specifically designed nanostructured surfaces that allow the imaging of different drugs with high sensitivity and reproducibility. Among several nanomaterials, we tested the behavior of gold and titanium nanoparticles, and halloysites and carbon nanotubes as possible matrices. All nanomaterials were firstly screened by co-spotting them with drugs on a MALDI plate, evaluating the drug signal intensity and the signal-to-noise ratio. The best performing matrices were tested on control tumor slices, and were spotted with drugs to check the ion suppression effect of the biological matrix. Finally; the best nanomaterials were employed in a preliminary drug distribution study inside tumors from treated mice. Full article

(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)

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Review

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Open AccessFeature PaperReview Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

by Minghua Lu, Xueqing Yang, Yixin Yang, Peige Qin, Xiuru Wu and Zongwei Cai

Nanomaterials 2017, 7(4), 87; doi:10.3390/nano7040087

Received: 26 March 2017 / Revised: 12 April 2017 / Accepted: 19 April 2017 / Published: 21 April 2017

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Abstract

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Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds. Full article

(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)

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Open AccessFeature PaperReview Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

by Rosaria Anna Picca, Cosima Damiana Calvano, Nicola Cioffi and Francesco Palmisano

Nanomaterials 2017, 7(4), 75; doi:10.3390/nano7040075

Received: 13 February 2017 / Revised: 24 March 2017 / Accepted: 28 March 2017 / Published: 2 April 2017

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Abstract

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Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques. Full article

(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)

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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: TiO2 coated silicon nanowires for phosphopeptides enrichement and their detection by LDI-MS
Authors: Yannick Coffinier*
Abstract: In this study we propose to fabricated composite materials based on TiO2 coating on silicon nanowires for the phosphopeptides enrichment and their subsequent detection by mass spectrometry through laser desorption/ionization method. To do so, we used different approaches for the fabrication including metallization (Ti deposition) or atomic layer deposition (ALD) for TiO2 deposition. Then, the different composite materials were assessed and compared in terms of their performances for phosphopeptide enrichment and MS signal intensities.

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