Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging
AbstractMultiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r2 = 678.9 ± 29.0 mM‒1·s‒1 at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1 at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 3355 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Cho, M.; Cervadoro, A.; Ramirez, M.R.; Stigliano, C.; Brazdeikis, A.; Colvin, V.L.; Civera, P.; Key, J.; Decuzzi, P. Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging. Nanomaterials 2017, 7, 72.
Cho M, Cervadoro A, Ramirez MR, Stigliano C, Brazdeikis A, Colvin VL, Civera P, Key J, Decuzzi P. Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging. Nanomaterials. 2017; 7(4):72.Chicago/Turabian Style
Cho, Minjung; Cervadoro, Antonio; Ramirez, Maricela R.; Stigliano, Cinzia; Brazdeikis, Audrius; Colvin, Vicki L.; Civera, Pierluigi; Key, Jaehong; Decuzzi, Paolo. 2017. "Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging." Nanomaterials 7, no. 4: 72.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.