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Nanomaterials 2016, 6(8), 151; doi:10.3390/nano6080151

Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities

1
Grupo de Nanovacunas y Vaculas Celulares Basadas en Listeria y Sus Aplicaciones en Biomedicina, Instituto de Investigación Marqués de Valdecilla, Avda. Cardenal Herrera Oria S/N, 39011 Santander, Cantabria, Spain
2
Servicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Avda. Valdecilla 25, 39008 Santander, Cantabria, Spain
3
CIC-biomaGUNE. P de Miramon, 20009 San Sebastian, Gipuzcoa, Spain
4
Biomedical Research Networking Center in Bioingeneering, Nanomaterials and Nanomedine (CIBER-BBN), P de Miramon 182, 20009 San Sebastian, Gipuzkoa, Spain
5
Servicio de Dermatología, Hospital Universitario Marqués de Valdecilla, Avda. Valdecilla 25, 39008 Santander, Cantabria, Spain
These authors contributed equally in this study.
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Nann
Received: 16 July 2016 / Revised: 26 July 2016 / Accepted: 12 August 2016 / Published: 19 August 2016
(This article belongs to the Special Issue Nanoparticles in Immunology)
View Full-Text   |   Download PDF [1452 KB, uploaded 19 August 2016]   |  

Abstract

Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91–99 (LLO91–99) or glyceraldehyde-3-phosphate dehydrogenase 1–22 peptide (GAPDH1–22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes. Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta. View Full-Text
Keywords: glyconanoparticles; listeria peptides; vaccines; melanocytes glyconanoparticles; listeria peptides; vaccines; melanocytes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Calderón-Gonzalez, R.; Terán-Navarro, H.; Frande-Cabanes, E.; Ferrández-Fernández, E.; Freire, J.; Penadés, S.; Marradi, M.; García, I.; Gomez-Román, J.; Yañez-Díaz, S.; Álvarez-Domínguez, C. Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities. Nanomaterials 2016, 6, 151.

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