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Nanomaterials 2016, 6(8), 139; doi:10.3390/nano6080139

DNA-Based Enzyme Reactors and Systems

1
Biohybrid Materials, Department of Biotechnology and Chemical Technology, Aalto University, P.O. Box 16100, Aalto 00076, Finland
2
Department of Physics, University of Jyvaskyla, Nanoscience Center, P.O. Box 35, Jyväskylä 40014, Finland
*
Authors to whom correspondence should be addressed.
Academic Editor: Leonid Gurevich
Received: 8 June 2016 / Revised: 11 July 2016 / Accepted: 19 July 2016 / Published: 27 July 2016
(This article belongs to the Special Issue DNA-Based Nanotechnology)
View Full-Text   |   Download PDF [2132 KB, uploaded 27 July 2016]   |  

Abstract

During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways. Moreover, sophisticated DNA structures can be utilized in encapsulating active enzymes and delivering the molecular cargo into cells. In this review, we focus on the latest enzyme systems based on novel DNA nanostructures: enzyme reactors, regulatory devices and carriers that can find uses in various biotechnological and nanomedical applications. View Full-Text
Keywords: DNA nanotechnology; DNA origami; self-assembly; enzyme; cascade reactions; DNA nanodevice; DNA sensors; drug-delivery; nanomedicine DNA nanotechnology; DNA origami; self-assembly; enzyme; cascade reactions; DNA nanodevice; DNA sensors; drug-delivery; nanomedicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Linko, V.; Nummelin, S.; Aarnos, L.; Tapio, K.; Toppari, J.J.; Kostiainen, M.A. DNA-Based Enzyme Reactors and Systems. Nanomaterials 2016, 6, 139.

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