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Nanomaterials 2016, 6(4), 71; doi:10.3390/nano6040071

Gold Nanoparticles: An Efficient Antimicrobial Agent against Enteric Bacterial Human Pathogen

1
Department of Physics, University of Engineering & Technology, Lahore 54890, Pakistan
2
Centre for Excellence in Solid State Physics, University of Punjab, Lahore 54590, Pakistan
3
Department of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editor: Neil O’Brien-Simpson
Received: 13 December 2015 / Revised: 29 January 2016 / Accepted: 24 February 2016 / Published: 14 April 2016
(This article belongs to the Special Issue Recent Advances in Nanomaterials’ Research: Selection from ICSSP'15)
View Full-Text   |   Download PDF [3198 KB, uploaded 14 April 2016]   |  

Abstract

Enteric bacterial human pathogens, i.e., Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Klebsiella pneumoniae, are the major cause of diarrheal infections in children and adults. Their structure badly affects the human immune system. It is important to explore new antibacterial agents instead of antibiotics for treatment. This project is an attempt to explain how gold nanoparticles affect these bacteria. We investigated the important role of the mean particle size, and the inhibition of a bacterium is dose-dependent. Ultra Violet (UV)-visible spectroscopy revealed the size of chemically synthesized gold nanoparticle as 6–40 nm. Atomic force microscopy (AFM) analysis confirmed the size and X-ray diffractometry (XRD) analysis determined the polycrystalline nature of gold nanoparticles. The present findings explained how gold nanoparticles lyse Gram-negative and Gram-positive bacteria. View Full-Text
Keywords: gold nanoparticles; chemical reduction method; enteric bacterial human pathogens; gram-negative and gram-positive bacteria gold nanoparticles; chemical reduction method; enteric bacterial human pathogens; gram-negative and gram-positive bacteria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shamaila, S.; Zafar, N.; Riaz, S.; Sharif, R.; Nazir, J.; Naseem, S. Gold Nanoparticles: An Efficient Antimicrobial Agent against Enteric Bacterial Human Pathogen. Nanomaterials 2016, 6, 71.

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