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Nanomaterials 2016, 6(3), 46; doi:10.3390/nano6030046

Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae

Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China
Authors to whom correspondence should be addressed.
Academic Editors: Jonathan Judy and Yoshihiro Ito
Received: 29 December 2015 / Revised: 22 February 2016 / Accepted: 1 March 2016 / Published: 9 March 2016
View Full-Text   |   Download PDF [2122 KB, uploaded 9 March 2016]   |  


A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment. View Full-Text
Keywords: hydrogel; drug release; long-term release time; anti-cercariae hydrogel; drug release; long-term release time; anti-cercariae

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, Y.; Zhu, L.; Fan, Y.; Li, Y.; Cheng, L.; Liu, W.; Li, X.; Fan, X. Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae. Nanomaterials 2016, 6, 46.

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