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Nanomaterials 2015, 5(4), 2019-2053; doi:10.3390/nano5042019

Recent Advance on Mesoporous Silica Nanoparticles-Based Controlled Release System: Intelligent Switches Open up New Horizon

Research Center for Bioengineering & Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Jordi Sort and Eva Pellicer
Received: 30 September 2015 / Revised: 25 October 2015 / Accepted: 28 October 2015 / Published: 25 November 2015
(This article belongs to the Special Issue Frontiers in Mesoporous Nanomaterials)
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Abstract

Mesoporous silica nanoparticle (MSN)-based intelligent transport systems have attracted many researchers’ attention due to the characteristics of uniform pore and particle size distribution, good biocompatibility, high surface area, and versatile functionalization, which have led to their widespread application in diverse areas. In the past two decades, many kinds of smart controlled release systems were prepared with the development of brilliant nano-switches. This article reviews and discusses the advantages of MSN-based controlled release systems. Meanwhile, the switching mechanisms based on different types of stimulus response are systematically analyzed and summarized. Additionally, the application fields of these devices are further discussed. Obviously, the recent evolution of smart nano-switches promoted the upgrading of the controlled release system from the simple “separated” switch to the reversible, multifunctional, complicated logical switches and selective switches. Especially the free-blockage switches, which are based on hydrophobic/hydrophilic conversion, have been proposed and designed in the last two years. The prospects and directions of this research field are also briefly addressed, which could be better used to promote the further development of this field to meet the needs of mankind. View Full-Text
Keywords: controlled release; mesoporous materials; smart materials; stimulus response; nano-switch; free-blockage switch controlled release; mesoporous materials; smart materials; stimulus response; nano-switch; free-blockage switch
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, R.; Wang, W.; Wen, Y.; Zhang, X. Recent Advance on Mesoporous Silica Nanoparticles-Based Controlled Release System: Intelligent Switches Open up New Horizon. Nanomaterials 2015, 5, 2019-2053.

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