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Nanomaterials 2015, 5(3), 1418-1430; doi:10.3390/nano5031418

Comparison of the in Vitro Uptake and Toxicity of Collagen- and Synthetic Polymer-Coated Gold Nanoparticles

1
Fachbereich Physik, Philipps Universität Marburg, Marburg 35037, Germany
2
Faculty of Physics, Babeş-Bolyai University, Cluj-Napoca 400084, Romania
3
CIC Biomagune, San Sebastian 20009, Spain
4
Dr. von Hauner Children’s Hospital, Ludwig Maximilians University, Munich 80337, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Subramanian Tamil Selvan
Received: 3 August 2015 / Revised: 19 August 2015 / Accepted: 20 August 2015 / Published: 27 August 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
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Abstract

We studied the physico-chemical properties (size, shape, zeta-potential), cellular internalization and toxicity of gold nanoparticles (NPs) stabilized with the most abundant mammalian protein, collagen. The properties of these gold NPs were compared to the same sized gold NPs coated with synthetic poly(isobutylene-alt-maleic anhydride) (PMA). Intracellular uptake and cytotoxicity were assessed in two cell lines (cervical carcinoma and lung adenocarcinoma cells) by employing inductively-coupled plasma-mass spectrometry (ICP-MS) analysis and a cell viability assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), respectively. We found that the collagen-coated gold NPs exhibit lower cytotoxicity, but higher uptake levels than PMA-coated gold NPs. These results demonstrate that the surface coating of Au NPs plays a decisive role in their biocompatibility. View Full-Text
Keywords: gold nanoparticles; cellular uptake; toxicity; biocompatibility gold nanoparticles; cellular uptake; toxicity; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marisca, O.T.; Kantner, K.; Pfeiffer, C.; Zhang, Q.; Pelaz, B.; Leopold, N.; Parak, W.J.; Rejman, J. Comparison of the in Vitro Uptake and Toxicity of Collagen- and Synthetic Polymer-Coated Gold Nanoparticles. Nanomaterials 2015, 5, 1418-1430.

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