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Nanomaterials 2015, 5(3), 1379-1396; doi:10.3390/nano5031379

Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging

Department of Pharmaceutics, School of Pharmaceutical Science, Shandong University, Ji’nan 250012, China
Department of Radiology Medicine, Affiliated Qilu Hospital, Shandong University, Ji’nan 250012, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Thomas Nann
Received: 1 June 2015 / Revised: 28 July 2015 / Accepted: 13 August 2015 / Published: 20 August 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
View Full-Text   |   Download PDF [3184 KB, uploaded 20 August 2015]   |  


Molecular imaging is essential to increase the sensitivity and selectivity of cancer diagnosis especially at the early stage of tumors. Recently, polyionic nanocomplexes (PICs), which are composed of polyanions and opposite polycations, have been demonstrated to be a promising strategy for biomedical applications. In this work, chitosan-hyaluronic acid nanoparticles (GCHN) were developed to deliver Gd-DTPA as MRI contrast agents for tumor diagnosis. The Gd-labeled conjugates (CS-DTPA-Gd) were successfully synthesized by carbodiimide reaction, and then GCHN were prepared by ionic gelation using the obtained CS-DTPA-Gd and hyaluronic acid. The morphology of GCHN was spherical or ellipsoidal, which is observed by transmission electronic microscopy (TEM). The mean particle size and zeta potential of GCHN were 213.8 ± 2.6 nm and 19.92 ± 1.69 mV, respectively. The significant enhancement of signal intensity induced by GCHN was observed both in vitro and in vivo. Also, compared with Magnevist, GCHN was witnessed for a prolonged imaging time in the B16 tumor-bearing mice model. Furthermore, GCHN were verified as below toxic both in vitro and in vivo. These results indicated that GCHN could potentially be an alternative to current MRI contrast agents for tumor diagnosis. View Full-Text
Keywords: tumor imaging; magnetic resonance imaging; hyaluronic acid; chitosan nanoparticles; Gd-DTPA tumor imaging; magnetic resonance imaging; hyaluronic acid; chitosan nanoparticles; Gd-DTPA

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, L.; Liu, T.; Xiao, Y.; Yu, D.; Zhang, N. Hyaluronic Acid-Chitosan Nanoparticles to Deliver Gd-DTPA for MR Cancer Imaging. Nanomaterials 2015, 5, 1379-1396.

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