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Nanomaterials 2014, 4(2), 508-521; doi:10.3390/nano4020508
Review

Carbon Nanotubes and Chronic Granulomatous Disease

1
, 2
 and 1,*
Received: 4 April 2014; in revised form: 15 May 2014 / Accepted: 12 June 2014 / Published: 23 June 2014
(This article belongs to the Special Issue Nanotoxicology)
View Full-Text   |   Download PDF [206 KB, uploaded 23 June 2014]
Abstract: Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles are ubiquitous in non-manufacturing environments and detectable in vapors from diesel fuel, methane, propane, and natural gas. In experimental animal models, carbon nanotubes have been shown to induce granulomas or other inflammatory changes. Evidence suggesting potential involvement of carbon nanomaterials in human granulomatous disease, has been gathered from analyses of dusts generated in the World Trade Center disaster combined with epidemiological data showing a subsequent increase in granulomatous disease of first responders. In this review we will discuss evidence for similarities in the pathophysiology of carbon nanotube-induced pulmonary disease in experimental animals with that of the human granulomatous disease, sarcoidosis.
Keywords: carbon nanotubes; sarcoidosis; alveolar macrophages carbon nanotubes; sarcoidosis; alveolar macrophages
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Barna, B.P.; Judson, M.A.; Thomassen, M.J. Carbon Nanotubes and Chronic Granulomatous Disease. Nanomaterials 2014, 4, 508-521.

AMA Style

Barna BP, Judson MA, Thomassen MJ. Carbon Nanotubes and Chronic Granulomatous Disease. Nanomaterials. 2014; 4(2):508-521.

Chicago/Turabian Style

Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary J. 2014. "Carbon Nanotubes and Chronic Granulomatous Disease." Nanomaterials 4, no. 2: 508-521.


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