Special Issue "Nanotoxicology"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 31 March 2014
Prof. Dr. Robert Tanguay
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331-4003, USA
Phone: +1 541 737 6514
Fax: +1 541 737 0497
Interests: developmental toxicity; high throughput screening; nanotoxicology; zebrafish; gene expression, miRNAs, and systems toxicology
Nanomaterial science continues to advance with the generation of more complex nanostructures with exciting potential applications. There have been parallel advances in the biological sciences aimed at evaluating the biocompatibility of these novel nanoparticles. Over recent years, we have realized that evaluating nanoparticles and biological interactions is quite complex because local environmental conditions influences particle behavior, and thus biocompatibility. In order to advance the development of safer high performing products, we need to understand the structural basis for these dynamic behaviors.
In this Special Issue, we are especially interested in manuscripts that advance the understanding of the specific nanomaterials attributes that govern or influence nanomaterial behavior and biocompatibility. This Issue invites manuscripts ranging from understanding dynamic behaviors of particles in aqueous environment, cellular toxicity, whole animal toxicity, neurotoxicity, immunotoxicity, genotoxicity, and population scale effects. Manuscripts that define specific biological responses at the organismal, gene expression, proteomic, and genetic levels are also invited.
Prof. Dr. Robert Tanguay
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- in vivo
- in vitro
- safety assessment
- nanoparticle characterization
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Mechanisms underlying cytotoxicity induced by engineered nanomaterials: A review of in vitro studies
Authors: Daniele R. Nogueira 1, Montserrat Mitjans 2 and M. Pilar Vinardell 2,*
1Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
2Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain
Abstract: Engineered nanomaterials are an emerging class of functional materials with technologically interesting properties and a wide range of promising applications, such as in drug delivery devices, medical imaging and diagnostics, and in other various industrial products. However, concerns have been expressed about the risks of such materials and whether they can cause adverse effects. Studies of the potential hazards of nanomaterials have been widely performed using cell models and a range of in vitro approaches. In the present review, we provide a comprehensive and critical literature overview on current in vitro toxicity test methods that have been applied to determine the mechanisms underlying the cytotoxic effects induced by the nanostructures. Nanomaterial features, such as small size, surface charge, hydrophobicity and high adsorption capacity, allow specific interactions within cell membrane and subcellular organelles, which in turn might lead to cytotoxicity through a range of different mechanisms. Finally, the given information on the relationships of nanomaterial cytotoxic responses with its structure and physicochemical properties might cooperate for the design of biologically safe nanostructures.
Last update: 3 December 2013