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Nanomaterials 2014, 4(2), 408-438; doi:10.3390/nano4020408

Superparamagnetic Nanoparticles for Atherosclerosis Imaging

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Received: 25 March 2014 / Revised: 15 May 2014 / Accepted: 16 May 2014 / Published: 5 June 2014
(This article belongs to the Special Issue Magnetic Nanomaterials)
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Abstract: The production of magnetic nanoparticles of utmost quality for biomedical imaging requires several steps, from the synthesis of highly crystalline magnetic cores to the attachment of the different molecules on the surface. This last step probably plays the key role in the production of clinically useful nanomaterials. The attachment of the different biomolecules should be performed in a defined and controlled fashion, avoiding the random adsorption of the components that could lead to undesirable byproducts and ill-characterized surface composition. In this work, we review the process of creating new magnetic nanomaterials for imaging, particularly for the detection of atherosclerotic plaque, in vivo. Our focus will be in the different biofunctionalization techniques that we and several other groups have recently developed. Magnetic nanomaterial functionalization should be performed by chemoselective techniques. This approach will facilitate the application of these nanomaterials in the clinic, not as an exception, but as any other pharmacological compound.
Keywords: iron oxide nanoparticles; cardiovascular imaging; atherosclerosis plaque; chemoselective functionalization iron oxide nanoparticles; cardiovascular imaging; atherosclerosis plaque; chemoselective functionalization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Herranz, F.; Salinas, B.; Groult, H.; Pellico, J.; Lechuga-Vieco, A.V.; Bhavesh, R.; Ruiz-Cabello, J. Superparamagnetic Nanoparticles for Atherosclerosis Imaging. Nanomaterials 2014, 4, 408-438.

AMA Style

Herranz F, Salinas B, Groult H, Pellico J, Lechuga-Vieco AV, Bhavesh R, Ruiz-Cabello J. Superparamagnetic Nanoparticles for Atherosclerosis Imaging. Nanomaterials. 2014; 4(2):408-438.

Chicago/Turabian Style

Herranz, Fernando; Salinas, Beatriz; Groult, Hugo; Pellico, Juan; Lechuga-Vieco, Ana V.; Bhavesh, Riju; Ruiz-Cabello, J. 2014. "Superparamagnetic Nanoparticles for Atherosclerosis Imaging." Nanomaterials 4, no. 2: 408-438.

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