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J. Funct. Biomater. 2017, 8(4), 46; doi:10.3390/jfb8040046

Fe Core–Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer

1
Department of Physics, University of Texas at Arlington; Arlington, TX 76019, USA
2
Advanced Imaging Research Center, Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
3
NanoScope Technologies LLC, Bedford, TX 76022, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Stefan H. Bossmann
Received: 22 April 2017 / Revised: 8 September 2017 / Accepted: 29 September 2017 / Published: 9 October 2017
(This article belongs to the Special Issue Magnetic Nanoparticle Design for Medical Diagnosis and Therapy)
View Full-Text   |   Download PDF [1957 KB, uploaded 9 October 2017]   |  

Abstract

The aim of this study is to fabricate a hybrid composite of iron (Fe) core–carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core–shell nanoparticles are synthesized using a one-step top–down approach through the electric plasma discharge generated in the cavitation field in organic solvents by an ultrasonic horn. Transmission electron microscopy (TEM) observations revealed the core–shell nanoparticles with 10–85 nm in diameter with excellent dispersibility in water without any agglomeration. TEM showed the structural confirmation of Fe nanoparticles with body centered cubic (bcc) crystal structure. Magnetic multi-functional hybrid composites of Fe core–C shell nanoparticles were then evaluated as negative MRI contrast agents, displaying remarkably high transverse relaxivity (r2) of 70 mM−1·S−1 at 7 T. This simple one-step synthesis procedure is highly versatile and produces desired nanoparticles with high efficacy as MRI contrast agents and potential utility in other biomedical applications. View Full-Text
Keywords: MRI; contrast agent; superparamagnetic; core-shell nanoparticles MRI; contrast agent; superparamagnetic; core-shell nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chaudhary, R.P.; Kangasniemi, K.; Takahashi, M.; Mohanty, S.K.; Koymen, A.R. Fe Core–Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer. J. Funct. Biomater. 2017, 8, 46.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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