Next Article in Journal
Color Stability of New Esthetic Restorative Materials: A Spectrophotometric Analysis
Next Article in Special Issue
Collective Migration of Lens Epithelial Cell Induced by Differential Microscale Groove Patterns
Previous Article in Journal
Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function
Previous Article in Special Issue
Metal Ion-Loaded Nanofibre Matrices for Calcification Inhibition in Polyurethane Implants
Article Menu

Export Article

Open AccessFeature PaperArticle
J. Funct. Biomater. 2017, 8(3), 25; doi:10.3390/jfb8030025

An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization

1
Department of Mechanical Engineering, Faculty of Engineering and Architectural Science, Ryerson University, 350 Victoria Street, Toronto, ON M5B 2K3, Canada
2
Keenan Research Centre, St. Michael’s Hospital, Toronto, ON M5B 1T8, Canada
3
Division of Oral & Maxillofacial Surgery & Anaesthesia, Faculty of Dentistry, University of Toronto, Toronto, ON M5G 1G6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Antonella Sola
Received: 8 May 2017 / Revised: 19 June 2017 / Accepted: 30 June 2017 / Published: 5 July 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
View Full-Text   |   Download PDF [5138 KB, uploaded 5 July 2017]   |  

Abstract

Glass polyalkenoate cements (GPCs) have potential as bio-adhesives due to their ease of application, appropriate mechanical properties, radiopacity and chemical adhesion to bone. Aluminium (Al)-free GPCs have been discussed in the literature, but have proven difficult to balance injectability with mechanical integrity. For example, zinc-based, Al-free GPCs reported compressive strengths of 63 MPa, but set in under 2 min. Here, the authors design injectable GPCs (IGPCs) based on zinc-containing, Al-free silicate compositions containing GeO2, substituted for ZnO at 3% increments through the series. The setting reactions, injectability and mechanical properties of these GPCs were evaluated using both a hand-mix (h) technique, using a spatula for sample preparation and application and an injection (i) technique, using a 16-gauge needle, post mixing, for application. GPCs ability to act as a carrier for bovine serum albumin (BSA) was also evaluated. Germanium (Ge) and BSA containing IGPCs were produced and reported to have working times between 26 and 44 min and setting times between 37 and 55 min; the extended handling properties being as a result of less Ge. The incorporation of BSA into the cement had no effect on the handling and mechanical properties, but the latter were found to have increased compression strength with the addition of Ge from between 27 and 37 MPa after 30 days maturation. View Full-Text
Keywords: fracture fixation; distal radius fracture; germanium oxide; polyacrylic acid; injectable glass polyalkenoate cements; bovine serum albumin fracture fixation; distal radius fracture; germanium oxide; polyacrylic acid; injectable glass polyalkenoate cements; bovine serum albumin
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Khader, B.A.; Peel, S.A.F.; Towler, M.R. An Injectable Glass Polyalkenoate Cement Engineered for Fracture Fixation and Stabilization. J. Funct. Biomater. 2017, 8, 25.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top