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J. Funct. Biomater. 2017, 8(1), 9; doi:10.3390/jfb8010009

Induction of Low-Level Hydrogen Peroxide Generation by Unbleached Cotton Nonwovens as Potential Wound Dressing Materials

1
United States Department of Agriculture, Southern Regional Research Center, New Orleans, LA 70124, USA
2
Plastic and Reconstructive Surgery, Virginia Commonwealth University, Richmond, VA 23111, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Kazuo Azuma
Received: 15 September 2016 / Revised: 18 February 2017 / Accepted: 23 February 2017 / Published: 6 March 2017
(This article belongs to the Special Issue Advanced Biomaterials for Wound Healing)
View Full-Text   |   Download PDF [1434 KB, uploaded 6 March 2017]   |  

Abstract

Greige cotton is an intact plant fiber. The cuticle and primary cell wall near the outer surface of the cotton fiber contains pectin, peroxidases, superoxide dismutase (SOD), and trace metals, which are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. Traditionally, the processing of cotton into gauze involves scouring and bleaching processes that remove the components in the cuticle and primary cell wall. The use of unbleached, greige cotton fibers in dressings, has been relatively unexplored. We have recently determined that greige cotton can generate low levels of H2O2 (5–50 micromolar). Because this may provide advantages for the use of greige cotton-based wound dressings, we have begun to examine this in more detail. Both brown and white cotton varieties were examined in this study. Brown cotton was found to have a relatively higher hydrogen peroxide generation and demonstrated different capacities for H2O2 generation, varying from 1 to 35 micromolar. The H2O2 generation capacities of white and brown nonwoven greige cottons were also examined at different process stages with varying chronology and source parameters, from field to nonwoven fiber. The primary cell wall of nonwoven brown cotton appeared very intact, as observed by transmission electron microscopy, and possessed higher pectin levels. The levels of pectin, SOD, and polyphenolics, correlated with H2O2 generation. View Full-Text
Keywords: hydrogen peroxide; chronic wounds; cotton; wound dressings; wound healing hydrogen peroxide; chronic wounds; cotton; wound dressings; wound healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Edwards, J.V.; Prevost, N.T.; Nam, S.; Hinchliffe, D.; Condon, B.; Yager, D. Induction of Low-Level Hydrogen Peroxide Generation by Unbleached Cotton Nonwovens as Potential Wound Dressing Materials. J. Funct. Biomater. 2017, 8, 9.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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