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J. Funct. Biomater. 2015, 6(3), 889-900; doi:10.3390/jfb6030889

Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Clinical Orthopaedics, Department of Clinical and Molecular Science, School of Medicine, Università Politecnica delle Marche, via Tronto 10/A, 60126 Ancona, Italy
Research and Development Department, Permedica S.p.A., via Como 38, 23807 Merate (LC), Italy
Author to whom correspondence should be addressed.
Academic Editor: Rajshree Mootanah
Received: 1 July 2015 / Revised: 24 July 2015 / Accepted: 8 August 2015 / Published: 8 September 2015
(This article belongs to the Special Issue Advances in the Tribology of Artificial Hip and Knee Joints)
View Full-Text   |   Download PDF [223 KB, uploaded 8 September 2015]


Since polyethylene is one of the most frequently used biomaterials, such as in bearing components in joint arthroplasty, strong efforts have been made to improve the design and material properties over the last decades. Antioxidants, such as vitamin-E, seem to be a promising alternative to further increase durability and reduce polyethylene wear and degradation in the long-term. Nevertheless, even if several promising in vitro results are available, there is yet no clinical evidence that vitamin-E polyethylenes show these advantages in vivo. The aim of this paper was to provide a comprehensive overview on the current knowledge regarding the biological and mechanical proprieties of this biomaterial, underlying the in vitro and in vivo evidence for effectiveness of vitamin-E-doped polyethylene in joint arthroplasty. View Full-Text
Keywords: α-tocopherol; polyethylene; vitamin E stabilized UHMPWE; total joints replacement α-tocopherol; polyethylene; vitamin E stabilized UHMPWE; total joints replacement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gigante, A.; Bottegoni, C.; Ragone, V.; Banci, L. Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review. J. Funct. Biomater. 2015, 6, 889-900.

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