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J. Funct. Biomater. 2011, 2(2), 67-87; doi:10.3390/jfb2020067

Mechanotransduction: Tuning Stem Cells Fate

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Received: 6 May 2011 / Revised: 7 June 2011 / Accepted: 17 June 2011 / Published: 21 June 2011
(This article belongs to the Special Issue Stem Cells and Biomaterials)
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Abstract: It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.
Keywords: ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

D’Angelo, F.; Tiribuzi, R.; Armentano, I.; Kenny, J.M.; Martino, S.; Orlacchio, A. Mechanotransduction: Tuning Stem Cells Fate. J. Funct. Biomater. 2011, 2, 67-87.

AMA Style

D’Angelo F, Tiribuzi R, Armentano I, Kenny JM, Martino S, Orlacchio A. Mechanotransduction: Tuning Stem Cells Fate. Journal of Functional Biomaterials. 2011; 2(2):67-87.

Chicago/Turabian Style

D’Angelo, Francesco; Tiribuzi, Roberto; Armentano, Ilaria; Kenny, Josè Maria; Martino, Sabata; Orlacchio, Aldo. 2011. "Mechanotransduction: Tuning Stem Cells Fate." J. Funct. Biomater. 2, no. 2: 67-87.

J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert