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Mechanotransduction: Tuning Stem Cells Fate
Department of Experimental Medicine and Biochemical Science, Section of Biochemistry and Molecular Biology, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Materials Engineering Centre, UdR INSTM, NIPLAB, University of Perugia, Strada di Pentima 4, 05100 Terni, Italy
Institute of Polymer Science and Technology, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
* Authors to whom correspondence should be addressed.
Received: 6 May 2011; in revised form: 7 June 2011 / Accepted: 17 June 2011 / Published: 21 June 2011
Abstract: It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.
Keywords: ESCs; ASCs; iPS; mechanotransduction; regenerative medicine; tissue engineering
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D’Angelo, F.; Tiribuzi, R.; Armentano, I.; Kenny, J.M.; Martino, S.; Orlacchio, A. Mechanotransduction: Tuning Stem Cells Fate. J. Funct. Biomater. 2011, 2, 67-87.
D’Angelo F, Tiribuzi R, Armentano I, Kenny JM, Martino S, Orlacchio A. Mechanotransduction: Tuning Stem Cells Fate. Journal of Functional Biomaterials. 2011; 2(2):67-87.
D’Angelo, Francesco; Tiribuzi, Roberto; Armentano, Ilaria; Kenny, Josè Maria; Martino, Sabata; Orlacchio, Aldo. 2011. "Mechanotransduction: Tuning Stem Cells Fate." J. Funct. Biomater. 2, no. 2: 67-87.