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J. Clin. Med. 2017, 6(7), 74; doi:10.3390/jcm6070074

The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease

Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
Received: 27 April 2017 / Revised: 1 July 2017 / Accepted: 12 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
View Full-Text   |   Download PDF [206 KB, uploaded 21 July 2017]

Abstract

Behcet’s disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD. View Full-Text
Keywords: Behcet’s disease; IL-17; Th17; regulatory T cells; Th1 Behcet’s disease; IL-17; Th17; regulatory T cells; Th1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nanke, Y.; Yago, T.; Kotake, S. The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease. J. Clin. Med. 2017, 6, 74.

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