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J. Clin. Med. 2017, 6(7), 73; doi:10.3390/jcm6070073

Th17 in Animal Models of Rheumatoid Arthritis

Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Sakyoku Syogoin Kawaramachi 54, Kyoto 606-8507, Japan
Received: 29 April 2017 / Revised: 13 July 2017 / Accepted: 15 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
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Abstract

IL-17-secreting helper CD4 T cells (Th17 cells) constitute a newly identified subset of helper CD4 T cells that play a key role in the development of rheumatoid arthritis (RA) in its animal models. Recently, several models of spontaneous RA, which elucidate the mechanism of RA onset, have been discovered. These animal models shed new light on the role of Th17 in the development of autoimmune arthritis. Th17 cells coordinate inflammation and promote joint destruction, acting on various cells, including neutrophils, macrophages, synovial fibroblasts, and osteoclasts. Regulatory T cells cannot control Th17 cells under conditions of inflammation. In this review, the pathogenic role of Th17 cells in arthritis development, which was revealed by the recent animal models of RA, is discussed. View Full-Text
Keywords: IL-17-secreting helper CD4 T cells (Th17 cells); animal models; rheumatoid arthritis; synovial fibroblasts; regulatory T cells IL-17-secreting helper CD4 T cells (Th17 cells); animal models; rheumatoid arthritis; synovial fibroblasts; regulatory T cells
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Hashimoto, M. Th17 in Animal Models of Rheumatoid Arthritis. J. Clin. Med. 2017, 6, 73.

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