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J. Clin. Med. 2017, 6(7), 70; doi:10.3390/jcm6070070

Omega-3 Polyunsaturated Fatty Acids for the Treatment of IgA Nephropathy

Apheresis and Dialysis Center, Keio Univerisity School of Medicine, Tokyo 1608582, Japan
Academic Editors: Fiorella Gurrieri and Eugenio Sangiorgi
Received: 17 April 2017 / Revised: 7 July 2017 / Accepted: 12 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Molecular Biology of IgA Nephropathy)
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Abstract

IgA nephropathy is a common disease that causes end-stage renal failure and requires renal replacement therapy. The main purpose of therapeutic intervention in this disease is not limited to improvement of prognosis and prevention of transition to end-stage renal failure, but also prevention of the occurrence of cardiovascular lesions, which increases risk in patients with chronic kidney disease. Steroids and immunosuppressants have been widely used as remission induction therapies; however, the balance between their therapeutic benefits and detrimental side-effects are controversial. In this regard, it is critical to identify alternative therapies which would provide holistic life-long benefits. Currently, the potential of ω-3 fatty acids as anti-inflammatory and inflammation-convergent drugs—especially the remarkable progress of the multifunctional ω-3 polyunsaturated fatty acids (PUFAs)—has garnered attention. In this section, we outline the background and current status of ω-3 PUFA-based treatment in IgA nephropathy. View Full-Text
Keywords: ω-3 PUFAs; EPA; DHA; IgA nephropathy; aspirin ω-3 PUFAs; EPA; DHA; IgA nephropathy; aspirin
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Hirahashi, J. Omega-3 Polyunsaturated Fatty Acids for the Treatment of IgA Nephropathy. J. Clin. Med. 2017, 6, 70.

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