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J. Clin. Med. 2017, 6(7), 68; doi:10.3390/jcm6070068

Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases

1
Univ-Lyon, CarMeN Laboratory, Inserm U1060, INRA U1397, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, F-69600 Oullins, France
2
Clinical Research Department, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, F-69495 Pierre Bénite, France
*
Author to whom correspondence should be addressed.
Received: 30 April 2017 / Revised: 3 July 2017 / Accepted: 4 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Th17 Cell in Autoimmune and Inflammatory Diseases)
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Abstract

Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in obese individuals are the former site of progressive infiltration by pro-inflammatory immune cells, which together with increased inflammatory adipokine secretion induce adipocyte insulin resistance. IL-17-producing T (Th17) cells are part of obese AT infiltrating cells, and are likely to be promoted by adipose tissue-derived mesenchymal stem cells, as previously reported by our team. Whereas Th17 cell are physiologically implicated in the neutralization of fungal and bacterial pathogens through activation of neutrophils, they may also play a pivotal role in the onset and/or progression of chronic inflammatory diseases, or cancer, in which obesity is recognized as a risk factor. In this review, we will highlight the pathogenic role of IL-17A producing cells in the mechanisms leading to inflammation in obesity and to progression of obesity-related inflammatory diseases. View Full-Text
Keywords: obesity; IL-17-producing T (IL-17) cells; adipose-derived-stem-cells; inflammatory diseases; immuno-metabolism obesity; IL-17-producing T (IL-17) cells; adipose-derived-stem-cells; inflammatory diseases; immuno-metabolism
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Chehimi, M.; Vidal, H.; Eljaafari, A. Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases. J. Clin. Med. 2017, 6, 68.

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